Meta AnalysisID 731
丁苯酞联合阿替普酶治疗急性脑梗死：一项系统评价与Meta分析
CRD42022351510
The aim of this meta-analysis is to systematically evaluate the efficacy and safety of Dl-3-n-Butylphthalide combined with alteplase in the treatment of acute stroke
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 731
- Evidence Id
- 9289
- Core Evidence Id
- 9289
- Source Meta Analysis Id
- 708
- Herb2 Meta Analysis Id
- HBMA000708
- Crd Id
- CRD42022351510
- Title
- Dl-3-n-Butylphthalide combined with alteplase for acute cerebral infarction: a systematic review and meta-analysis
- Review Question
- The aim of this meta-analysis is to systematically evaluate the efficacy and safety of Dl-3-n-Butylphthalide combined with alteplase in the treatment of acute stroke
- Study Type Included
- Randomized controlled trial (RCT)
- Condition Being Studied
- Stroke disease, is abrupt faint servant, unconscious, hemiplegia, mouth eye askew, language disadvantage is the main disease syndrome. Acute period is within 2 weeks after onset, the viscera can be extended to 1 month. Stroke is the second cause of death among people over 60 years old worldwide and has become the first cause of death for elderly patients in China. High morbidity, high mortality and high disability rate are the important characteristics of this disease. Western medicine mainly focuses on routine treatment, including airway patency, intracranial pressure reduction and brain protection.
- Participant
- Inclusion criteria: Patients diagnosed as ischemic stroke were confirmed by CT/MRI according to the diagnostic criteria of acute cerebral infarction published in the 2019 Chinese Guidelines for the Diagnosis and Treatment of Acute cerebral infarction or other authoritative institutions; Patients diagnosed with acute stage of ischemic stroke, cerebral infarction and cerebral thrombosis confirmed by CT/MRI according to The 2018 Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke .There are no country, age or gender restrictions Exclusion criteria: The diagnostic criteria of the design scheme are not clear; Cerebrovascular diseases caused by trauma, intracranial vascular malformation and cerebral arteritis; Repeated publication;Animal experiments, conference documents, expert experience, case reports and reviews.
- Animal
- Human Disease Modelled
- Intervention
- The experimental group was treated with Dl-3-n-Butylphthalide and alteplase on the basis of conventional treatment .
- Comparator Control
- The control group received alteplase and/or routine treatment
- Main Outcome
- Clinical effective rate, infarct size, NIHSS score，Barthel score, ADLscore,
- Outcome Measure
- Additional Outcome
- inflammatory factors（TNF-α, CRP, IL-6, IL-1, IL-8）, Oxidative stress, SOD, MDA，Vascular endothelial function（VEGF）, NO，ET-1
- Study Method
- Meta-analysis, Systematic review
- Keyword
- 3-n-butylphthalide; Benzofurans; Cerebral Infarction; Humans; Myocardial Infarction; Tissue Plasminogen Activator
- Contact
- xinxin Liu [email protected]
- Organisational Affiliation
- Shandong University of Traditional Chinese Medicine
- Funding Source
- Key R & D Program of the People’s Republic of China (2019YFC1711700)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-05
- Registration Date
- 2022-08-15
- Anticipated Start Date
- 2022-08-20
- Anticipated Completion Date
- 2022-09-30
- Title Cn
- 丁苯酞联合阿替普酶治疗急性脑梗死：一项系统评价与Meta分析
- Title En
- Dl-3-n-Butylphthalide combined with alteplase for acute cerebral infarction: a systematic review and meta-analysis
- Bilingual Status
- complete