Meta AnalysisID 7304
青蒿素类复方疗法疗效监测及撒哈拉以南非洲十年间恶性疟原虫抗疟药耐药分子标志物趋势：系统评价与Meta分析
CRD42023432718
What are the efficacy and evolution of resistance molecular markers of malaria drugs in sub-Saharan Africa over ten years?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7304
- Evidence Id
- 15862
- Core Evidence Id
- 15862
- Source Meta Analysis Id
- 7292
- Herb2 Meta Analysis Id
- HBMA007292
- Crd Id
- CRD42023432718
- Title
- Monitoring of the efficacy of artemisinin-based combination therapies and trend of resistance molecular markers of Plasmodium falciparum to antimalarial drugs over ten years in sub-Saharan Africa: a systematic review and meta-analysis
- Review Question
- What are the efficacy and evolution of resistance molecular markers of malaria drugs in sub-Saharan Africa over ten years?
- Study Type Included
- Inclusion criteria For efficacy and effectiveness studies o Original articles of studies that investigated the efficacy or effectiveness of at least one recommended ACT for the treatment of uncomplicated P. falciparum; o Study samples collected between 2010 – 2021 o Studies performed in Sub-Saharan Africa For Resistance molecular markers review o Clinical trials comprising analysis of one or more malaria resistance molecular markers (Pfcrt, Pfmdr, Pfdhps, Pfdhfr, Pfk13, Pfpm2) o Observational studies (Cross-sectional/cohort studies/) involving detection of the prevalence of the mutation in at least one of the genes (Pfcrt, Pfcrt, Pfmdr, Pfdhps, Pfdhfr, Pfk13, Pfpm2)
- Condition Being Studied
- The systematic review focuses on malaria treatment. It contains two parts. First, we will analyse the efficacy of artemisinin-based combination therapy five years after its scale-up in many countries. Second, we will examine the trend of molecular resistance markers over ten years using ACT.
- Participant
- - Inclusion: patients with Plasmodium falciparum infection, regardless of age or sex, living in sub-Saharan Africa - Exclusion: Expats living in Africa
- Animal
- Human Disease Modelled
- Intervention
- Use of artemisinin agents in the treatment of uncomplicated malaria
- Comparator Control
- Main Outcome
- - Efficacy review Uncorrected and corrected Adequate clinical and parasitological response (ACPR) by Day 28 or 42 - Resistance molecular markers review Prevalence of malaria resistance molecular markers (Pfcrt, Pfmdr1, PfK13, dhps, dhfr, plasmepsin 2, Pfmdr1 number of copy) Measures of effect - Proportion of ACPR - Prevalence
- Outcome Measure
- Additional Outcome
- - Early treatment failure (ETF) - Late clinical failure (LCF) - Late parasitological failure (LPF) - Parasite clearance half-life Measures of effect Proportions
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Africa South of the Sahara; Antimalarials; Artemisinins; Humans; Malaria; Plasmodium falciparum; artemisinin
- Contact
- Francis Bohissou [email protected]
- Organisational Affiliation
- 1. Institute of Tropical Medicine, University Hospital Tübingen, 72074 Tübingen, Germany. 2. Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso. 3. Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin
- Funding Source
- PAMAfrica/EDCTP This systematic review is funded through the EDCTP-funded project PAMAfrica (Portofolio approach to developing the next generations of malaria treatments for Africa). This study is part 1 of the PhD project, which aims at assessing the temporal trends of Plasmodium falciparum resistance molecular markers over ten-year sin Burkina Faso.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Benin, Burkina Faso, Germany
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-05
- Registration Date
- 2023-06-16
- Anticipated Start Date
- 2022-06-01
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 青蒿素类复方疗法疗效监测及撒哈拉以南非洲十年间恶性疟原虫抗疟药耐药分子标志物趋势：系统评价与Meta分析
- Title En
- Monitoring of the efficacy of artemisinin-based combination therapies and trend of resistance molecular markers of Plasmodium falciparum to antimalarial drugs over ten years in sub-Saharan Africa: a systematic review and meta-analysis
- Bilingual Status
- complete