Meta AnalysisID 73
活血化瘀类中药对痛经的效果：一项系统评价与Meta分析
CRD42022297018
Compared with placebo or NSAIDs, what are the effects of Chinese herbal medicine for promoting blood circulation in preventing dysmenorrhea in women? We aim to generate a clinically helpful summary of the interventions b
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 73
- Evidence Id
- 8631
- Core Evidence Id
- 8631
- Source Meta Analysis Id
- 67
- Herb2 Meta Analysis Id
- HBMA000067
- Crd Id
- CRD42022297018
- Title
- Effect of Chinese herbal medicine for promoting circulation on dysmenorrhea: A systematic review and meta-analysis
- Review Question
- Compared with placebo or NSAIDs, what are the effects of Chinese herbal medicine for promoting blood circulation in preventing dysmenorrhea in women? We aim to generate a clinically helpful summary of the interventions based on their efficacy.
- Study Type Included
- Randomized controlled trials (RCTs) will be included, animal experiments are not included.
- Condition Being Studied
- Dysmenorrhea, one of the most common gynecological diseases of menstruating women in the world, is divided into primary dysmenorrhea and secondary dysmenorrhea. The main clinical manifestations consisted of lower abdominal pain and swelling during menstruation, accompanied by backache or other discomforts. Some severe symptoms even affect the quality of life of women. Primary dysmenorrhea without organic disease in the reproductive organs; while secondary dysmenorrhea refers to pelvic organic diseases, such as endometriosis, adenomyosis, etc. Primary dysmenorrhea is more common in adolescence and often comes 1~2 years after menarche，mainly related to increased prostaglandin content in the endometrium. The high content of PGF2α can cause excessive contraction of uterine smooth muscle, vasospasm, and cause dysmenorrhea due to uterine ischemia and hypoxia. Therefore, non-steroidal anti-inflammatory drugs are commonly used to treat primary dysmenorrhea, but the condition is repeated and has certain adverse reactions. The symptoms of secondary dysmenorrhea are the same as those of primary dysmenorrhea. Secondary pain caused by endometriosis is often progressive aggravation, and adenomyosis is manifested as menstrual abnormalities (menorrhagia, prolonged menstruation, and irregular bleeding), which are usually treated after differential diagnosis.
- Participant
- Inclusion: Women diagnosed with primary or secondary dysmenorrhea (as diagnosed using any recognized diagnostic criteria). Exclusion: Other abdominal pain or pelvic organic disease that is not accompanied by regular menstrual cycles.
- Animal
- Human Disease Modelled
- Intervention
- In the experimental group, Chinese herbal medicines with activating blood circulation and removing blood stasis were used as intervention measures to relieve pain (Such Chinese herbal medicines are usually used for cardiovascular diseases, mainly including Ligusticum chuanxiong, Danshen, peony, and prescriptions composed of them).
- Comparator Control
- In the control group, non-steroidal anti-inflammatory drugs or placebos were used.
- Main Outcome
- The main outcomes include:(1) Pain. (2) Clinical efficacy. Measures of effect (1) Pain: Measured by visual analog scales, other verification scales, or as a dichotomous result, pain reduction during or as a result of the intervention. (2) Clinical efficacy: Measured by changes in dysmenorrhea symptoms and treatment effects, or self-reports, observations, or other similar indicator reports, the overall relief of menstrual-related symptoms occurs during or after the intervention.
- Outcome Measure
- Additional Outcome
- (1) Quality of life assessment. (2) Adverse events.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Drugs, Chinese Herbal; Dysmenorrhea; Female; Humans
- Contact
- Fujia Jing [email protected]
- Organisational Affiliation
- Sichuan Univ, West China Hosp, Regenerat Med Res Ctr
- Funding Source
- No external funding was provided for this study.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-12-11
- Registration Date
- 2022-01-11
- Anticipated Start Date
- 2021-12-16
- Anticipated Completion Date
- 2022-08-17
- Title Cn
- 活血化瘀类中药对痛经的效果：一项系统评价与Meta分析
- Title En
- Effect of Chinese herbal medicine for promoting circulation on dysmenorrhea: A systematic review and meta-analysis
- Bilingual Status
- complete