Meta AnalysisID 7296
重金属和微量元素与多囊卵巢综合征女性氧化应激的关联：一项系统评价
CRD42023418453
Are heavy metals and trace elements associated with oxidative stress in women with polycystic ovary syndrome?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7296
- Evidence Id
- 15854
- Core Evidence Id
- 15854
- Source Meta Analysis Id
- 7284
- Herb2 Meta Analysis Id
- HBMA007284
- Crd Id
- CRD42023418453
- Title
- Heavy metals and trace elements in association with oxidative stress in women with polycystic ovary syndrome: a systematic review.
- Review Question
- Are heavy metals and trace elements associated with oxidative stress in women with polycystic ovary syndrome?
- Study Type Included
- The inclusion criteria will consist of case-control studies, randomized control studies, prospective, and descriptive studies. We will exclude studies other than in humans, reviews, and studies published in languages other than English.
- Condition Being Studied
- Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies with multifactorial etiology. Oxidative stress is known to be one of the pathways involved in PCOS pathogenesis and its metabolic associations. Serum levels of heavy metals and trace elements can change in PCOS women and can be associated with oxidative stress.
- Participant
- Inclusion criteria: patients of reproductive age diagnosed with PCOS Exclusion criteria: patients with a history of other endocrinopathies (e.g., Cushing syndrome, diabetes mellitus, congenital adrenal hyperplasia, thyroid dysfunction), a history of using drugs such as hormonal contraceptives or mineral supplementation at least 3 months before entering the study
- Animal
- Human Disease Modelled
- Intervention
- Intervention: trace elements (selenium, zinc, magnesium, chromium, calcium) supplementation, environmental exposure to heavy metals (e.g. lead, cadmium, mercury, arsenic) Exposure: markers of oxidative stress, serum metal levels, markers of low-grade inflammation, hormonal and metabolic variables in PCOS
- Comparator Control
- Healthy women of reproductive age with regular menstrual cycles and taking no medications. Placebo group.
- Main Outcome
- changes in blood levels of markers of oxidative stress in women with PCOS changes in blood levels of heavy metals and trace elements in women with PCOS association of markers of oxidative stress with heavy metals and trace elements in women with PCOS Measures of effect p-value
- Outcome Measure
- Additional Outcome
- hormonal and metabolic variables in PCOS, markers of low-grade chronic inflammation Measures of effect p-value
- Study Method
- Systematic review
- Keyword
- Female; Humans; Metals, Heavy; Oxidative Stress; Polycystic Ovary Syndrome; Trace Elements
- Contact
- Tinkara Srnovrsnik [email protected]
- Organisational Affiliation
- Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia Clinical Research Centre, University Medical Centre Ljubljana, Slovenia Faculty of Medicine, University of Ljubljana, Slovenia Community Health Centre Ljubljana, Slovenia https://www.kclj.si/ https://www.zd-lj.si/zdlj/index.php?option=com_content&view=featured&Itemid=2140&lang=en https://www.mf.uni-lj.si/en_GB
- Funding Source
- University Medical Centre Ljubljana, Slovenia Grant number(s) State the funder, grant or award number and the date of award In progress.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Slovenia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-18
- Registration Date
- 2023-04-29
- Anticipated Start Date
- 2023-04-01
- Anticipated Completion Date
- 2023-06-01
- Title Cn
- 重金属和微量元素与多囊卵巢综合征女性氧化应激的关联：一项系统评价
- Title En
- Heavy metals and trace elements in association with oxidative stress in women with polycystic ovary syndrome: a systematic review.
- Bilingual Status
- complete