Meta AnalysisID 7286
谷氨酸能系统在强迫性行为中的作用：一项系统评价
CRD42023485500
What impact do glutamatergic pharmacotherapies have on body-focused compulsive behaviors, relative to other drugs, placebo, or to non-pharmacological treatments?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7286
- Evidence Id
- 15844
- Core Evidence Id
- 15844
- Source Meta Analysis Id
- 7271
- Herb2 Meta Analysis Id
- HBMA007271
- Crd Id
- CRD42023485500
- Title
- The role of the glutamatergic system on compulsive behavior: A systematic review
- Review Question
- What impact do glutamatergic pharmacotherapies have on body-focused compulsive behaviors, relative to other drugs, placebo, or to non-pharmacological treatments?
- Study Type Included
- We will include peer-reviewed controlled trials in which body-focused compulsive behavior is one of the outcome measures (e.g., not only obsessions in OCD) Exclusion criteria: case studies, review papers, papers in which compulsive behavior is not an outcome measure
- Condition Being Studied
- Body-focused repetitive behaviors, and other compulsive grooming behaviors in humans or other species (e.g., trichotillomania, excoriation disorder in humans; compulsive grooming behavior in mice).
- Participant
- Inclusion: Humans and non-humans from childhood (> age 5) who display body-focused repetitive behaviors or other compulsive grooming behaviors
- Animal
- Human Disease Modelled
- Intervention
- Treatment with a glutamatergic drug, including but not limited to N-Acetylcysteine (NAC), memantine, minocycline, riluzole, L-carnosine, lamotrigine, ketamine, C-cycloserine, glycine, amantadine, topiramate, pregabalin
- Comparator Control
- Either placebo or comparison to other drug or other targeted psychotherapy intervention.
- Main Outcome
- Self-reports or professional assessment of compulsive behavior as compared to a control or comparison group, including but not limited to scores on common scales such as the NIMH Trichotillomania Symptom Severity Scale, the Massachusetts General Hospital Hairpulling Scale (MGH-HPS), Generic BFRB Scale 9 (GBS-9), the Trichotillomania Scale for Children (TSC-Child), or the Revised Skin Picking Scale (SPS-R), or a clinical interview.
- Outcome Measure
- Additional Outcome
- Where available, quantitative measurements of compulsive grooming behavior including physical damage, alopecia/hair loss, lesions, frequency of behavior, etc. in human and non-human animals.
- Study Method
- Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Emily Barkley-Levenson, Ph.D. [email protected]
- Organisational Affiliation
- Hofstra University https://www.hofstra.edu/psychology/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-11-21
- Registration Date
- 2023-12-03
- Anticipated Start Date
- 2023-12-01
- Anticipated Completion Date
- 2024-08-31
- Title Cn
- 谷氨酸能系统在强迫性行为中的作用：一项系统评价
- Title En
- The role of the glutamatergic system on compulsive behavior: A systematic review
- Bilingual Status
- complete