Meta AnalysisID 7261
α-硫辛酸补充对偏头痛治疗的影响：一项系统评价
CRD42023467716
Is alpha lipoic acid supplemmentation effective in migraine treatment?
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Record Fields
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- Meta Analysis Id
- 7261
- Evidence Id
- 15819
- Core Evidence Id
- 15819
- Source Meta Analysis Id
- 7246
- Herb2 Meta Analysis Id
- HBMA007246
- Crd Id
- CRD42023467716
- Title
- Effect of alpha lipoic acid supplementation on migraine treatment: A systematic review
- Review Question
- Is alpha lipoic acid supplemmentation effective in migraine treatment?
- Study Type Included
- Inclusions: RCT. Exclusions: Cohort studies, case-control studies, cross-sectional studies, in vitro studies, animal studies, reviews.
- Condition Being Studied
- Migraine is defined as a common, chronic, throbbing, weakening neurological disease, accompanied by a serious one-sided headache, nausea, vomiting, and photophobia. The exact pathophysiological mechanisms of migraine are not completely understood. However, according to studies, several hypotheses have been proposed in the pathogenesis of migraine. One of the recognized hypotheses on migraine is hypoxia or mitochondrial dysfunction; Hypoxia and mitochondrial dysfunction increase lactate levels in the brain of healthy, MA and MwoA subjects. In some previous studies, elevated serum lactate levels have been reported in patients with migraine (both MA and MwoA). In fact, elevated lactate reflects mitochondrial dysfunction, which may play an important role in migraines. When hypoxia affects tissue, endothelial cells release nitric oxide (NO), consequently increasing the vasodilatation response and oxygen supply to tissues. NO supersensitivity may be a possible molecular mechanism of migraine pain. NO is involved in stimulating cortical spreading depression (CSD) activity and consequently increasing cellular adhesion molecules (CAMs). CAM serum levels show elevated levels of intracellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM) in children and young adults with migraine.
- Participant
- Inclusions: Individuals with episodic or chronic migraine with or without aura or unspecified, diagnosed according to the International Classification of Headache Disorders criteria, without age or gender restrictions. Exclusions: other types of headaches, pregnant or lactating women, patients with chronic diseases or neurological disorders, use of migraine prophylactic medication or treatment measure in addition to pharmacological intervention, if any, for at least 4 weeks before entering the study.
- Animal
- Human Disease Modelled
- Intervention
- Inclusions: Alpha lipoic acid (thiotic acid) oral supplementation alone, instead of pharmacological intervention or add-on therapy, in any dose or time administered per day. Exclusions: Combined with other antioxidant supplements or use of alpha lipoic acid obtained in the diet.
- Comparator Control
- Inclusions: Placebo, no supplementation, pharmacological intervention. Exclusions: Other antioxidant supplementation.
- Main Outcome
- Headache severity: pain during the attack, in VAS or point scale (mild, moderate, severe, or similar). Headache duration: hours with pain. Headache frequency: days with migraine attacks per month. Measures of effect The standardized mean difference for headache severity, headache duration, and headache frequency after intervention or placebo in each selected study.
- Outcome Measure
- Additional Outcome
- Not applicable. Measures of effect Not applicable.
- Study Method
- Intervention, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Sergio Rivera [email protected]
- Organisational Affiliation
- Universidad de Los Andes https://www.uandes.cl/
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Chile
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-27
- Registration Date
- 2023-10-08
- Anticipated Start Date
- 2023-10-04
- Anticipated Completion Date
- 2023-12-13
- Title Cn
- α-硫辛酸补充对偏头痛治疗的影响：一项系统评价
- Title En
- Effect of alpha lipoic acid supplementation on migraine treatment: A systematic review
- Bilingual Status
- complete