Meta AnalysisID 7251
α-硫辛酸对非酒精性肝病和非酒精性脂肪性肝炎的疗效：临床试验的系统评价与Meta分析
CRD42023453955
What is the current state of evidence regarding alpha lipoic acid as a treatment for nonalcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7251
- Evidence Id
- 15809
- Core Evidence Id
- 15809
- Source Meta Analysis Id
- 7235
- Herb2 Meta Analysis Id
- HBMA007235
- Crd Id
- CRD42023453955
- Title
- The Efficacy of Alpha Lipoic Acid in Nonalcoholic Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta Analysis of Clinical Trials
- Review Question
- What is the current state of evidence regarding alpha lipoic acid as a treatment for nonalcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis?
- Study Type Included
- Clinical trials
- Condition Being Studied
- Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with a prevalence of 25% and characterized by different stages of progression such as non-alcoholic fatty liver (NAFL) (steatosis) and nonalcoholic steatohepatitis (NASH), that leads to cirrhosis. NAFLD and NASH are related to insulin resistance and metabolic syndrome. Some animal studies suggested that alpha-lipoic acid (ALA) can improve these disease outcomes. In addition, there is evidence of beneficial effects of ALA on metabolic disorders and insulin resistances.
- Participant
- Inclusion criteria: clinical trials, NAFLD/NASH patients Exclusion criteria: irretrievable full-text articles, incompatible language
- Animal
- Human Disease Modelled
- Intervention
- The interventions are products that consist of alpha lipoic acids.
- Comparator Control
- Placebo or other medications
- Main Outcome
- Changes from baseline in metabolic parameters (e.g. lipid profile, HbA1c, glucose parameter) and liver functions. Measures of effect No specific timing constrained on the duration of the intervention course. Effect sizes will be presented in mean differences or standardized mean differences.
- Outcome Measure
- Additional Outcome
- Data permitting, changes from baseline in: Anthropometric parameters (e.g. Body weight, and BMI) Markers of oxidative stress (e.g. malondialdehyde (MDA)) Inflammatory markers (e.g. C-reactive protein (CRP), Interleukin-1, Interleukin-6, monocyte chemoattractant protein-1 (MCP-1)) Iron profile (e.g. serum ferritin) Hematological profile (e.g. platelets) Radiological modalities (e.g steatosis score) NAFLD scoring tools (e.g NAFLD fibrosis score) Liver biopsy changes Measures of effect No specific timing constrained on the duration of the intervention course. Effect sizes will be presented in mean differences or standardized mean differences.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Digestive System Diseases; Humans; Non-alcoholic Fatty Liver Disease; Thioctic Acid
- Contact
- Alver Prasetya [email protected]
- Organisational Affiliation
- Atma Jaya Catholic University of Indonesia https://www.atmajaya.ac.id/id/
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Indonesia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-12
- Registration Date
- 2023-08-24
- Anticipated Start Date
- 2023-08-13
- Anticipated Completion Date
- 2023-09-17
- Title Cn
- α-硫辛酸对非酒精性肝病和非酒精性脂肪性肝炎的疗效：临床试验的系统评价与Meta分析
- Title En
- The Efficacy of Alpha Lipoic Acid in Nonalcoholic Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta Analysis of Clinical Trials
- Bilingual Status
- complete