Meta AnalysisID 725
脱氢表雄酮补充剂对接受体外受精/卵胞浆内单精子注射的女性卵巢卵丘细胞的影响——一项系统评价
CRD42022354272
Does DHEA supplementation improves oocyte cumulus cell functions of infertile women undergoing IVF/ICSI
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 725
- Evidence Id
- 9283
- Core Evidence Id
- 9283
- Source Meta Analysis Id
- 702
- Herb2 Meta Analysis Id
- HBMA000702
- Crd Id
- CRD42022354272
- Title
- Effects of Dehydroepiandrosterone (DHEA) Supplementation on Ovarian Cumulus Cells in Women undergoing In-Vitro Fertilization (IVF)/ Intra-Cytoplasmic Sperm Injection (ICSI) – A Systematic Review
- Review Question
- Does DHEA supplementation improves oocyte cumulus cell functions of infertile women undergoing IVF/ICSI
- Study Type Included
- We will include all Randomised controlled trial, case-control, cohort studies that assess the beneficial effect of DHEA in ovarian cumulus cells function.
- Condition Being Studied
- Despite many trials conducted to explore the effects of DHEA supplementation but its clinical use in IVF practices remains controversial due to the conflicting results and absence of well-designed large-scale randomised trials. Recent studies have reported that DHEA supplementation might influence gene expressions of Cumulus cells (CCs) in poor ovarian response women. Thus, investigation of the effect of DHEA on gene expression of CCs may be a good idea to identify the exact mechanisms of DHEA in follicular microenvironment.
- Participant
- Inclusion Criteria: Infertile women undergoing In-vitro Fertilisation / Intra-cytoplasmic sperm injection treatment Exclusion Criteria: Women with history of oophorectomy or history of pelvic irradiation or chemotherapy for malignancy or any treatment which affects the ovarian function.
- Animal
- Human Disease Modelled
- Intervention
- Supplementation with Dehydroepiandrosterone (any dosage / duration) prior to ovarian stimulation for IVF treatment.
- Comparator Control
- Group with similar characteristics but without DHEA supplementation prior to ovarian stimulation
- Main Outcome
- Any outcome in relation to cumulus cell function eg. gene expression, mitochondrial function assessment etc.
- Outcome Measure
- Additional Outcome
- Clinical outcomes eg stimulation outcome, cycle outcome and pregnancy outcome.
- Study Method
- Intervention, Systematic review
- Keyword
- Cumulus Cells; Dehydroepiandrosterone; Dietary Supplements; Female; Fertilization; Humans; Male; Sperm Injections, Intracytoplasmic; Spermatozoa
- Contact
- Shu Yuan Woon [email protected]
- Organisational Affiliation
- Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia
- Funding Source
- No funding in this review. Self initiated review.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Malaysia
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-17
- Registration Date
- 2022-08-28
- Anticipated Start Date
- 2022-08-21
- Anticipated Completion Date
- 2022-09-18
- Title Cn
- 脱氢表雄酮补充剂对接受体外受精/卵胞浆内单精子注射的女性卵巢卵丘细胞的影响——一项系统评价
- Title En
- Effects of Dehydroepiandrosterone (DHEA) Supplementation on Ovarian Cumulus Cells in Women undergoing In-Vitro Fertilization (IVF)/ Intra-Cytoplasmic Sperm Injection (ICSI) – A Systematic Review
- Bilingual Status
- complete