Meta AnalysisID 7249
α-硫辛酸减轻药物性神经毒性的疗效
CRD42023448233
Is alpha-lipoic acid effective in reducing drug-induced neurotoxicity?
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Record Fields
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- Meta Analysis Id
- 7249
- Evidence Id
- 15807
- Core Evidence Id
- 15807
- Source Meta Analysis Id
- 7233
- Herb2 Meta Analysis Id
- HBMA007233
- Crd Id
- CRD42023448233
- Title
- Efficacy of alpha-lipoic acid in reducing drug-induced neurotoxicity.
- Review Question
- Is alpha-lipoic acid effective in reducing drug-induced neurotoxicity?
- Study Type Included
- Only randomized controlled trials will be included.
- Condition Being Studied
- Although there are numerous studies that prove the safety of drugs, there are still several side effects that are not avoidable, such as neurotoxicity. Many studies focus on changing doses, adding medications, but leave aside the option of including nutraceuticals, which are proven to have an antioxidant effect, which can reduce the toxicity caused by medications. In fact, most studies with nutraceuticals do not bring alarming results, but on the other hand, the fact that they have few or no side effects would already be of great help for the body to strengthen itself against the toxicity resulting from the drugs. Likewise, individual assays lack sufficient power to detect significant differences in outcomes in important subgroups, such as those defined by age, polypharmacy, among others. Therefore, we intend to perform a systematic review and meta-analysis examining the efficacy of alpha-lipoic acid in patients with potential drug-induced neurotocity, specifically interested in outcomes such as improvement in neurotoxic symptoms, decrease in neurotoxicity progression, or improvement in patients' quality of life.
- Participant
- We will include randomized clinical trials (RCTs) comparing alpha lipoic acid with placebo in patients using any drug with potential neurotoxicity, reporting the clinical outcomes of interest. We will exclude animal studies, studies with overlapping patient populations, as well as studies without a control group.
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Alpha lipoic acid, also known as thioctic acid
- Comparator Control
- Control: placebo
- Main Outcome
- We will extract data for a joint analysis of the following outcomes: (1) improvement in neurotoxic symptoms; (2) decrease in the progression of neurotoxicity; and (3) improved quality of life. Measures of effect Hazards ratio.
- Outcome Measure
- Additional Outcome
- Symptoms of neurotoxicity in all causes; neuropathies; incapacitation; muscle pain and weakness; loss of function and cognition Measures of effect Hazards ratio or odds ratio.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Antioxidants; Humans; Neurotoxicity Syndromes; Thioctic Acid
- Contact
- Luciana Cancado [email protected]
- Organisational Affiliation
- Universidade NOVA de Lisboa https://www.unl.pt/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Portugal
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-24
- Registration Date
- 2023-08-05
- Anticipated Start Date
- 2023-07-17
- Anticipated Completion Date
- 2023-09-08
- Title Cn
- α-硫辛酸减轻药物性神经毒性的疗效
- Title En
- Efficacy of alpha-lipoic acid in reducing drug-induced neurotoxicity.
- Bilingual Status
- complete