Meta AnalysisID 7231
上肢再植术围手术期血栓预防：系统评价
CRD42023484753
What is the efficacy of various types of perioperative anticoagulation protocols on upper extremity replantation?
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Record Fields
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- Meta Analysis Id
- 7231
- Evidence Id
- 15789
- Core Evidence Id
- 15789
- Source Meta Analysis Id
- 7217
- Herb2 Meta Analysis Id
- HBMA007217
- Crd Id
- CRD42023484753
- Title
- Perioperative Thromboprophylaxis in Upper Extremity Replantation: A Systematic Review
- Review Question
- What is the efficacy of various types of perioperative anticoagulation protocols on upper extremity replantation?
- Study Type Included
- We will include randomized controlled trials, nonrandomized controlled trials, cohort studies, case–control studies, and case series to assess the various perioperative thromboprophylaxis protocols for upper extremity replantation and their success with survival of the limb/digit. We will exclude gray literature like expert opinion and single case report, unpublished literature, animal studies, and studies >40 years old.
- Condition Being Studied
- Upper extremity replantation and survival with type of thromboprophylaxis protocol used perioperatively.
- Participant
- Inclusion: humans of any age that underwent an upper extremity replantation where microvascular anastomosis occured Exclusion: animals
- Animal
- Human Disease Modelled
- Intervention
- Perioperative thromboprophylaxis includes local and systemic administration of thromboprophylactic agent and all dose regimens, as well as intra-operative hemodynamic/anesthesia recommendations and postoperative care for thromboprophylactic measures with the aim of successful take of an upper extremity replantation. Examples include lidocaine, heparin, aspirin, dextran, phosphodiesterase inhibitors, hemoprophylaxis, systemic vasodilators, as well as regional anesthesia and blood pressure parameters.
- Comparator Control
- Not applicable given this is a systematic review focused on the various protocols that exist surrounding perioperative thromboprophylaxis for the successful take of upper extremity replantation.
- Main Outcome
- The primary outcome measured will be success of upper extremity replantation defined by replantation survival which is an indication of microvascular patency from the anastomosis intervention. Measures of effect mean replant survival rate, % survival
- Outcome Measure
- Additional Outcome
- Secondary outcomes measured will be intervention-related complications and average hospital stay.
- Study Method
- Intervention, Synthesis of qualitative studies, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Nadiya Yerich [email protected]
- Organisational Affiliation
- Brooke Army Medical Center (BAMC) Department of Orthopaedic Surgery
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-11-20
- Registration Date
- 2023-11-30
- Anticipated Start Date
- 2023-11-22
- Anticipated Completion Date
- 2024-05-31
- Title Cn
- 上肢再植术围手术期血栓预防：系统评价
- Title En
- Perioperative Thromboprophylaxis in Upper Extremity Replantation: A Systematic Review
- Bilingual Status
- complete