Meta AnalysisID 7230
成人心脏手术体外循环预充液的管理：网状Meta分析
CRD42023416194
This network meta-analysis will compare the effects of all current priming fluids without hydroxyethyl starch used during CPB in adults undergoing cardiac surgery based on platelet count, mortality, mean CPB time, urine
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7230
- Evidence Id
- 15788
- Core Evidence Id
- 15788
- Source Meta Analysis Id
- 7216
- Herb2 Meta Analysis Id
- HBMA007216
- Crd Id
- CRD42023416194
- Title
- Management of Priming Fluids in Cardiopulmonary Bypass for Adult Cardiac Surgery: Network Meta-Analysis
- Review Question
- This network meta-analysis will compare the effects of all current priming fluids without hydroxyethyl starch used during CPB in adults undergoing cardiac surgery based on platelet count, mortality, mean CPB time, urine output 24h after surgery, length of intensive care unit (ICU) stay, length of hospital stay, blood loss 24h after surgery, and chest tube output within 24h after surgery, and further determine the best choice for priming fluid in CPB surgery. A lengthy investigation has led to 88 out of the 102 studies that Boldt has published since 1999 being withdrawn from the medical literature. He has been found guilty of research misconduct, including failure to acquire ethical approval and fabrication of study data, and sacked from his position as professor at Klinikum Ludwigshafen, a large teaching hospital in Ludwigshafen, Germany, where he carried out his research. The retraction of such a large body of work has had far reaching effects on clinical practice, research oversight, and editorial policies.
- Study Type Included
- Randomised controlled trial
- Condition Being Studied
- This network meta-analysis will compare the effects of all current priming fluids without hydroxyethyl starch used during CPB in adults undergoing cardiac surgery based on platelet count, mortality, mean CPB time, urine output 24h after surgery, length of intensive care unit (ICU) stay, length of hospital stay, blood loss 24h after surgery, and chest tube output within 24h after surgery, and further determine the best choice for priming fluid in CPB surgery.
- Participant
- All adults (>18 years old) who underwent cardiac surgery
- Animal
- Human Disease Modelled
- Intervention
- Various priming fluids were classified into eight categories, including balanced crystalloids (lactated Ringer's, Ringer acetate or Plasmalytes), 0.9% NaCl, iso-oncotic HA (4% iso-oncotic HA or 5% iso-oncotic HA), hyperoncotic HA (25%), HES with molecular weight 130k (L-HES), HES with molecular weight 200k (H-HES), gelatin (3.5% gelatin, 4% gelatin or gelofusine), and dextran.
- Comparator Control
- Other priming fluids.
- Main Outcome
- Platelet count, mortality
- Outcome Measure
- Additional Outcome
- Mean CPB time, urine output 24h after surgery, length of icu stay, length of hospital stay, blood loss 24h after surgery, and chest tube output within 24h after surgery
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Adult; Cardiopulmonary Bypass; Editorial Policies; Germany; Humans; Hydroxyethyl Starch Derivatives; Male; Scientific Misconduct
- Contact
- Chao Zhang [email protected]
- Organisational Affiliation
- Taihe Hospital, Hubei University of Medicine
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-11
- Registration Date
- 2023-04-22
- Anticipated Start Date
- 2023-04-10
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 成人心脏手术体外循环预充液的管理：网状Meta分析
- Title En
- Management of Priming Fluids in Cardiopulmonary Bypass for Adult Cardiac Surgery: Network Meta-Analysis
- Bilingual Status
- complete