Meta AnalysisID 7226
特布他林与肾上腺素治疗急诊儿科哮喘的有效性和安全性：随机对照试验的系统评价和Meta分析
CRD42023463676
What is the comparative efficacy and safety of terbutaline compared to epinephrine in the treatment of pediatric asthma in emergency settings,
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7226
- Evidence Id
- 15784
- Core Evidence Id
- 15784
- Source Meta Analysis Id
- 7212
- Herb2 Meta Analysis Id
- HBMA007212
- Crd Id
- CRD42023463676
- Title
- Efficacy and Safety of Terbutaline vs. Epinephrine for Treating Pediatric Asthma in Emergency: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Review Question
- What is the comparative efficacy and safety of terbutaline compared to epinephrine in the treatment of pediatric asthma in emergency settings,
- Study Type Included
- Randomized Controlled Trials
- Condition Being Studied
- The domain being studied in the research is the treatment of pediatric asthma, specifically comparing the effectiveness and safety of epinephrine (Epi) and terbutaline for this condition.
- Participant
- Inclusion: children and adolescents aged 18 years and under with acute asthma exacerbation in emergency settings. Exclusion: Adults >18 years of age
- Animal
- Human Disease Modelled
- Intervention
- Terbutaline is a medication commonly used to treat asthma. It belongs to a class of drugs known as beta-2 adrenergic agonists, which help to relax the airway muscles and alleviate symptoms of asthma, such as wheezing, shortness of breath, and coughing. In the context of your study, terbutaline is the primary treatment under investigation.
- Comparator Control
- While Epinephrine is another medication used in emergency situations to treat severe asthma exacerbations. It also acts on the airway muscles, dilating them and improving airflow. In your study, epinephrine is the reference or control treatment used to compare its efficacy and safety with terbutaline in treating pediatric asthma. Our study aims to compare how well terbutaline works in treating pediatric asthma in emergency situations compared to epinephrine, with a focus on both the effectiveness of symptom relief and the safety of these treatments in the pediatric population.
- Main Outcome
- The main outcomes of our study are 1. Safety and Efficacy of Terbutaline vs Epinephrine in Emergency Settings 2. Hospitalization 3. Length of stay in the emergency department greater than 24 hours 4. The need for intubation 5. Moratlity Measures of effect Mean differences in 95% CI's, percentages
- Outcome Measure
- Additional Outcome
- Secondary Outcomes: Peak Expiratory Flow Rate (PEFR) Forced Expiratory Volume in the First Second (FEV1) Heart Rate Length of Stay (other than greater than 24 hours, which is part of the primary outcome) Respiratory Rate Oxygen Saturation pH PCO2 (Partial Pressure of Carbon Dioxide) Lactate levels Occurrence of Adverse Events
- Study Method
- Living systematic review, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Mohammed Alsabri [email protected]
- Organisational Affiliation
- BROOKDALE Hospital
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-04
- Registration Date
- 2023-10-15
- Anticipated Start Date
- 2023-10-01
- Anticipated Completion Date
- 2024-09-10
- Title Cn
- 特布他林与肾上腺素治疗急诊儿科哮喘的有效性和安全性：随机对照试验的系统评价和Meta分析
- Title En
- Efficacy and Safety of Terbutaline vs. Epinephrine for Treating Pediatric Asthma in Emergency: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete