Meta AnalysisID 7223
院外心脏骤停中使用肾上腺素的系统评价与Meta分析：临床结局与安全性评估
CRD42023402645
Impact of epinephrine administration on survival and neurologic outcomes in out-of-hospital cardiac arrest patients, its limitations and potential harms associated with this intervention.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7223
- Evidence Id
- 15781
- Core Evidence Id
- 15781
- Source Meta Analysis Id
- 7209
- Herb2 Meta Analysis Id
- HBMA007209
- Crd Id
- CRD42023402645
- Title
- Systematic review and meta-analysis on Epinephrine Use in Out-of-Hospital Cardiac Arrest: An Examination of Clinical Outcomes and Safety.
- Review Question
- Impact of epinephrine administration on survival and neurologic outcomes in out-of-hospital cardiac arrest patients, its limitations and potential harms associated with this intervention.
- Study Type Included
- Types of studies to be included: Randomized controlled trials (RCTs), observational studies that investigate the use of epinephrine for cardiac arrest treatment in out-of-hospital settings. Types of studies to be excluded: Studies that focus on the use of epinephrine for cardiac arrest treatment in hospital settings or during surgical procedures, and do not report relevant outcomes or have incomplete data.
- Condition Being Studied
- Condition/Healthcare Domain: Cardiac Arrest The study falls within the domain of emergency medicine and resuscitation. It focuses on the use of epinephrine, a medication commonly used in emergency care settings, for the treatment of cardiac arrest that occurs outside of the hospital. This research is relevant to pre-hospital care providers, emergency medical services (EMS) personnel, and healthcare professionals involved in managing cardiac arrest events in out-of-hospital settings, with the goal of improving patient outcomes and informing evidence-based practices for emergency care.
- Participant
- Participants/population: Adults or aged or young adults or middle aged Inclusion criteria: Studies conducted on human participants, focusing on out-of-hospital cardiac arrest (OHCA) patients, evaluating the use of epinephrine in the management of OHCA. Exclusion criteria: Studies conducted on animals or in vitro models, not focusing on OHCA patients, not evaluating the use of epinephrine, without clinical outcomes or safety data available.
- Animal
- Human Disease Modelled
- Intervention
- Intervention(s), Exposure(s): Epinephrine or adrenaline or Racepinephrine The intervention of interest in this systematic review and meta-analysis is the use of epinephrine in the management of out-of-hospital cardiac arrest (OHCA) patients. Epinephrine, also known as adrenaline, is a medication commonly used during cardiopulmonary resuscitation (CPR) to stimulate the heart and increase blood flow to vital organs in an attempt to improve survival outcomes in OHCA patients. Exposures include the administration of epinephrine via different routes (e.g. intravenous, intraosseous, endotracheal), different dosages, and at different time points during the management of OHCA. This may also include comparisons between epinephrine and other interventions or medications used in the management of OHCA, such as placebo or alternative vasopressors.
- Comparator Control
- Non-use of prehospital epinephrine, achievement of pre-hospital Return of spontaneous circulation(ROSC)
- Main Outcome
- Return of spontaneous circulation (ROSC) achieved pre-hospital, Survived to hospital discharge, CPC 1 (normal function) or 2 (mild to moderate disability) Measures of effect Relative Risks, Odds ratios
- Outcome Measure
- Additional Outcome
- Study Method
- Cost effectiveness, Intervention, Meta-analysis, Systematic review
- Keyword
- Epinephrine; Humans; Out-of-Hospital Cardiac Arrest
- Contact
- Chandana Priya Badiginchala [email protected]
- Organisational Affiliation
- Indian Institute of Information and technology, Dharwad IIIT Dharwad Campus, Ittigatti Road, Near Sattur Colony, Dharwad 580009. 0836 2250879, 9449732959 [email protected].
- Funding Source
- Not Applicable Grant number(s) State the funder, grant or award number and the date of award NA
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-20
- Registration Date
- 2023-05-01
- Anticipated Start Date
- 2023-02-24
- Anticipated Completion Date
- 2023-05-22
- Title Cn
- 院外心脏骤停中使用肾上腺素的系统评价与Meta分析：临床结局与安全性评估
- Title En
- Systematic review and meta-analysis on Epinephrine Use in Out-of-Hospital Cardiac Arrest: An Examination of Clinical Outcomes and Safety.
- Bilingual Status
- complete