Meta AnalysisID 7222
腺苷辅助栓塞治疗脑动静脉畸形的安全性和有效性
CRD42023494116
P: Patients with newly diagnosed AVMs or with previously treated AVMs (either by surgery, embolization, or radiotherapy) I: Embolization assisted with adenosine C: no comparator O: AVM occlusion rates, AVM hemorrhage rat
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7222
- Evidence Id
- 15780
- Core Evidence Id
- 15780
- Source Meta Analysis Id
- 7208
- Herb2 Meta Analysis Id
- HBMA007208
- Crd Id
- CRD42023494116
- Title
- Safety and Efficacy of Adenosine-assisted Embolization of Brain Arteriovenous Malformations
- Review Question
- P: Patients with newly diagnosed AVMs or with previously treated AVMs (either by surgery, embolization, or radiotherapy) I: Embolization assisted with adenosine C: no comparator O: AVM occlusion rates, AVM hemorrhage rate, new-onset seizures, seizure improvement, seizure worsening, sensory and motor neurological deficits, mortality, adenosine-related events (i.e., Stroke, ECG change such as ST elevation, Q waves, and arrhythmias, creatinine elevation, among others) T: unrestricted follow-up time T: unrestricted type of studies
- Study Type Included
- There are no restrictions to the type of study and all original studies are included. Studies that will be excluded are non-original articles (letters, editorials, comments, systematic reviews, meta-analysis, narrative reviews, conference abstracts without, etc)
- Condition Being Studied
- Despite multiple studies, the safety and efficacy of Adenosine-assisted Embolization of Brain Arteriovenous Malformations on individual endpoints, such as mortality and AVM occlusion and haemorrhage rates, is not clear. Therefore, trials typically lack enough power for a definitive assessment of these endpoints. We aim to perform a systematic review and meta-analysis examining the safety and efficacy of Adenosine-assisted Embolization of Brain Arteriovenous Malformations, specifically interested in end-points such as AVM occlusion rates, AVM hemorrhage rate, new-onset seizures, seizure improvement, seizure worsening, sensory and motor neurological deficits, mortality, adenosine-related events, etc.
- Participant
- Patients with newly diagnosed AVMs or with previously treated AVMs (either by surgery, embolisation or radiotherapy)
- Animal
- Human Disease Modelled
- Intervention
- Embolization assisted with adenosine
- Comparator Control
- No comparator
- Main Outcome
- AVM occlusion rates, AVM hemorrhage rate, new-onset seizures, seizure improvement, seizure worsening, sensory and motor neurological deficits, mortality, adenosine-related events (i.e., Stroke, ECG change such as ST elevation, Q waves, and arrhythmias, creatinine elevation, among others) Measures of effect Since it's a proportional meta-analysis, data will be summarized as counts and proportions.
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Jhon E. Bocanegra-Becerra, MD [email protected]
- Organisational Affiliation
- Not applicable
- Funding Source
- Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil, India, Kuwait, Peru
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-16
- Registration Date
- 2023-12-26
- Anticipated Start Date
- 2023-12-16
- Anticipated Completion Date
- 2024-01-16
- Title Cn
- 腺苷辅助栓塞治疗脑动静脉畸形的安全性和有效性
- Title En
- Safety and Efficacy of Adenosine-assisted Embolization of Brain Arteriovenous Malformations
- Bilingual Status
- complete