Meta AnalysisID 7213
氢化可的松-氟氢可的松联合用药对脓毒性休克死亡率的影响：系统评价与Meta分析
CRD42023472376
This systematic review and meta-analysis is conducted to investigate the clinical efficacy and safety of the Hydrocortisone-Fludrocortisone combination in the treatment of patients with spetic shock. P: Septic shock I: H
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Record Fields
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- Meta Analysis Id
- 7213
- Evidence Id
- 15771
- Core Evidence Id
- 15771
- Source Meta Analysis Id
- 7200
- Herb2 Meta Analysis Id
- HBMA007200
- Crd Id
- CRD42023472376
- Title
- Effect of Hydrocortisone-Fludrocortisone Combination on Mortality in Septic Shock: A Systematic Review and Meta-Analysis
- Review Question
- This systematic review and meta-analysis is conducted to investigate the clinical efficacy and safety of the Hydrocortisone-Fludrocortisone combination in the treatment of patients with spetic shock. P: Septic shock I: Hydrocortisone-Fludrocortisone combination C: Hydrocortisone alone O: In-hospital mortality, length of hospital stay, length of intensive care unit stay, adverse events
- Study Type Included
- Randomized controlled trials and Observational studies
- Condition Being Studied
- Sepsis is a condition characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection [1]. In 2017, the Global Burden of Disease Study reported an estimated 48.9 million cases of sepsis (with a 95% uncertainty interval of 38.9-62.9 million), leading to 11.0 million deaths related to sepsis (within a range of 10.1-12.0 million) and these sepsis-related fatalities accounted for approximately 19.7% of all global deaths. Nevertheless, the impact of adjunctive hydrocortisone on short- or long-term mortality remains a topic of debate, possibly due to variations in treatment regimens. Some randomized clinical trials (RCTs), like the VANISH trial and ADRENAL trial, exclusively employed hydrocortisone, while other studies utilized a combination of hydrocortisone and fludrocortisone. However, some studies have not observed a clinically significant benefit of hydrocortisone-fludrocortisone combination therapy for treating septic shock. Therefore, this systematic review and meta-analysis were conducted to elucidate the effect of hydrocortisone-fludrocortisone combination therapy in patients with septic shock, with a particular focus on mortality.
- Participant
- Patients with septic shock
- Animal
- Human Disease Modelled
- Intervention
- Hydrocortisone-Fludrocortisone combination
- Comparator Control
- Hydrocortisone alone
- Main Outcome
- In-hospital mortality
- Outcome Measure
- Additional Outcome
- ICU mortality, 28-day mortality, 90-day mortality, 180-day mortality, one-year mortality, vasopressor-free duration, vasopressor duration, length of hospital stay, length of ICU stay, mechanical ventilation free days, and the risk of adverse events
- Study Method
- Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Jheng-Yan Wu [email protected]
- Organisational Affiliation
- Chi Mei Medical Center
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Taiwan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-13
- Registration Date
- 2023-10-24
- Anticipated Start Date
- 2023-10-13
- Anticipated Completion Date
- 2023-11-11
- Title Cn
- 氢化可的松-氟氢可的松联合用药对脓毒性休克死亡率的影响：系统评价与Meta分析
- Title En
- Effect of Hydrocortisone-Fludrocortisone Combination on Mortality in Septic Shock: A Systematic Review and Meta-Analysis
- Bilingual Status
- complete