Meta AnalysisID 721
左甲状腺素治疗对甲状腺自身免疫且甲状腺功能正常的孕妇妊娠及新生儿结局的影响：一项系统评价、Meta分析和试验序贯分析
CRD42022346745
P: euthyroid pregnant women with thyroid autoimmunity; I: levothyroxine; C: placebo or without treatment; O: pregnancy and neonatal outcomes; S: RCTs and cohort studies
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 721
- Evidence Id
- 9279
- Core Evidence Id
- 9279
- Source Meta Analysis Id
- 698
- Herb2 Meta Analysis Id
- HBMA000698
- Crd Id
- CRD42022346745
- Title
- The impact of levothyroxine therapy on pregnancy and neonatal outcomes in euthyroid pregnant women with thyroid autoimmunity: a systematic review, meta-analysis and trial sequential analysis
- Review Question
- P: euthyroid pregnant women with thyroid autoimmunity; I: levothyroxine; C: placebo or without treatment; O: pregnancy and neonatal outcomes; S: RCTs and cohort studies
- Study Type Included
- RCT and cohort study are eligible for inclusion.
- Condition Being Studied
- Thyroid autoimmunity is characterized by elevated thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) and present in 2% to 17% of pregnant women.
- Participant
- Euthyroid pregnant women with positive TPOAb and/or TgAb. The diagnosis was based on the diagnostic criteria in the 2017 ATA guideline.
- Animal
- Human Disease Modelled
- Intervention
- Oral levothyroxine. Dosages and treatment duration were not limited
- Comparator Control
- Placebo or no treatment.
- Main Outcome
- Miscarriage, preterm birth, live birth, gestational hypertension, preeclampsia. Measures of effect Dichotomous outcomes without zero-events: relative risks (RCT) and odds ratios(cohort study); Dichotomous outcomes with zero-events: Peto's OR; Continuous data: mean difference
- Outcome Measure
- Additional Outcome
- placenta abruption, gestational age at delivery, birth weight, neonatal admission Measures of effect Dichotomous outcomes without zero-events: relative risks (RCT) and odds ratios(cohort study); Dichotomous outcomes with zero-events: Peto's OR; Continuous data: mean difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Autoimmunity; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Outcome; Pregnant Women; Thyroid Gland; Thyroxine
- Contact
- Jingjing Chen [email protected]
- Organisational Affiliation
- West China Second University Hospital, Sichuan University https://www.motherchildren.com/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-15
- Registration Date
- 2022-07-26
- Anticipated Start Date
- 2022-04-01
- Anticipated Completion Date
- 2022-08-20
- Title Cn
- 左甲状腺素治疗对甲状腺自身免疫且甲状腺功能正常的孕妇妊娠及新生儿结局的影响：一项系统评价、Meta分析和试验序贯分析
- Title En
- The impact of levothyroxine therapy on pregnancy and neonatal outcomes in euthyroid pregnant women with thyroid autoimmunity: a systematic review, meta-analysis and trial sequential analysis
- Bilingual Status
- complete