Meta AnalysisID 7207
脓毒性休克中氢化可的松治疗的时机与结局
CRD42023451825
Primary objective: Assess whether early administration of hydrocortisone in septic shock improves patient mortality and use of vasopressors in days Secondary objectives: Assess whether early administration of hydrocortis
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7207
- Evidence Id
- 15765
- Core Evidence Id
- 15765
- Source Meta Analysis Id
- 7194
- Herb2 Meta Analysis Id
- HBMA007194
- Crd Id
- CRD42023451825
- Title
- Timing of hydrocortisone therapy in septic shock and outcomes
- Review Question
- Primary objective: Assess whether early administration of hydrocortisone in septic shock improves patient mortality and use of vasopressors in days Secondary objectives: Assess whether early administration of hydrocortisone in septic shock decreases ICU and hospital length of stay, decreases use of dialysis, decreases intubation rates, and decreases intubation length
- Study Type Included
- randomized controlled studies
- Condition Being Studied
- Septic shock is a prevalent disease with significant mortality and morbidity in critically ill patients. Hydrocortisone therapy is recommended in shock patients with ongoing needs for vasopressors (moderate evidence). The exact timing with earlier administration could potentially improve outcomes.
- Participant
- Adults admitted to the intensive care unit who are in septic shock and receive hydrocortisone for shock
- Animal
- Human Disease Modelled
- Intervention
- hydrocortisone administration with early administration, within 1-12 hours of vasopressors
- Comparator Control
- hydrocortisone administration with late administration, after 12 hours of vasopressors
- Main Outcome
- mortality and reduced vasopressor requirement Measures of effect risk ratio and mean difference
- Outcome Measure
- Additional Outcome
- ICU and hospital length of stay, decreases use of dialysis, decreases intubation rates, and decreases intubation length Measures of effect risk ratio and mean difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Hydrocortisone; Intensive Care Units; Intubation, Intratracheal; Length of Stay; Renal Dialysis; Shock, Septic; Vasoconstrictor Agents
- Contact
- Scott Helgeson [email protected]
- Organisational Affiliation
- Mayo Clinic
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-14
- Registration Date
- 2023-08-25
- Anticipated Start Date
- 2023-08-14
- Anticipated Completion Date
- 2023-11-30
- Title Cn
- 脓毒性休克中氢化可的松治疗的时机与结局
- Title En
- Timing of hydrocortisone therapy in septic shock and outcomes
- Bilingual Status
- complete