Meta AnalysisID 7200
脓毒性休克患者中使用氟氢可的松联合氢化可的松对比单用氢化可的松：一项系统评价与Meta分析
CRD42023431857
Do the association of hydrocortisone and fludrocortisone decrease mortality in patients with septic shock?
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Record Fields
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- Meta Analysis Id
- 7200
- Evidence Id
- 15758
- Core Evidence Id
- 15758
- Source Meta Analysis Id
- 7187
- Herb2 Meta Analysis Id
- HBMA007187
- Crd Id
- CRD42023431857
- Title
- Use of Fludrocortisone and Hydrocortisone vs use of Hydrocortisone Alone Among Patients With Septic Shock: a systematic review and meta-analysis
- Review Question
- Do the association of hydrocortisone and fludrocortisone decrease mortality in patients with septic shock?
- Study Type Included
- Randomized controlled trials and observational studies will be included.
- Condition Being Studied
- The administration of corticosteroids has shown potential benefits for patients with septic shock. However, despite multiple studies, there is still uncertainty regarding the comparative effectiveness between two commonly studied corticosteroid regimens: hydrocortisone with fludrocortisone versus hydrocortisone alone. Recent publications have demonstrated a numerical decrease in mortality by 3% with the combination therapy. Nevertheless, the potential advantages of incorporating fludrocortisone to hydrocortisone for the treatment of septic shock remain inconclusive. Consequently, our aim is to conduct a systematic review and meta-analysis to evaluate the efficacy of hydrocortisone and fludrocortisone combination in patients with septic shock. We will specifically focus on endpoints such as mortality, as well as outcomes related to ICU and hospital length of stay, and the shock reversal.
- Participant
- We will include randomized controlled trials (RCTs) and observational studies comparing the use of hydrocortisone and fludrocortisone with the use of hydrocortisone in patients with shock septic, reporting the clinical outcomes of interest. We will exclude studies with overlapping patient populations, as well as studies without a control group.
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Hydrocortisone and fludrocortisone
- Comparator Control
- Control: hydrocortisone
- Main Outcome
- We will extract data for a pooled analysis on the following outcomes: (1) all-cause mortality; (2)ICU and hospital length of days; and (3)shock reversal. Measures of effect Hazards ratio
- Outcome Measure
- Additional Outcome
- Mechanical Ventilator Free days, Vasopressor free days, organ failure free days Measures of effect Hazards ratio or odds ratio.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Fludrocortisone; Hospital Mortality; Humans; Hydrocortisone; Patients; Shock, Septic
- Contact
- ANNA CAROLINA MACIEL, MD [email protected]
- Organisational Affiliation
- Funding Source
- none Grant number(s) State the funder, grant or award number and the date of award none
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-02
- Registration Date
- 2023-06-12
- Anticipated Start Date
- 2023-05-01
- Anticipated Completion Date
- 2023-07-01
- Title Cn
- 脓毒性休克患者中使用氟氢可的松联合氢化可的松对比单用氢化可的松：一项系统评价与Meta分析
- Title En
- Use of Fludrocortisone and Hydrocortisone vs use of Hydrocortisone Alone Among Patients With Septic Shock: a systematic review and meta-analysis
- Bilingual Status
- complete