Meta AnalysisID 72
泰式传统医学或草药治疗COVID-19的疗效与安全性：一项系统评价与Meta分析
CRD42021274861
Are Thai traditional medicines (TTMs) or herbal medicines therapies effective for treatment of patients confirmed or suspected with COVID-19?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 72
- Evidence Id
- 8630
- Core Evidence Id
- 8630
- Source Meta Analysis Id
- 66
- Herb2 Meta Analysis Id
- HBMA000066
- Crd Id
- CRD42021274861
- Title
- Efficacy and safety of Thai traditional medicine or herbal medicine for treatment of the COVID-19: A systematic review and meta-analysis.
- Review Question
- Are Thai traditional medicines (TTMs) or herbal medicines therapies effective for treatment of patients confirmed or suspected with COVID-19?
- Study Type Included
- We will include both randomised controlled trials (RCTs) and non-RCTs, regardless of level of blinding. We will also include observational study such as pre-post study, case control or cohort study.
- Condition Being Studied
- Alternative or additive treatments of COVID-19 using Thai traditional medicines or herbal medicines.
- Participant
- Patients confirmed or suspected with COVID-19, regardless of disease severity, age, gender, setting or previous treatments.
- Animal
- Human Disease Modelled
- Intervention
- Any Thai traditional medicine or herbal medicine regimen (monotherapy or combination) that available or widely used in Thailand such as Harak remedy, Turmeric, Kaempfer, Andrographis paniculata or FaThalai Chon (in Thai). We will exclude studies evaluating any Chinese medicine or complementary medicines, nutritional supplements/dietary modifications, or non-pharmacotherapy.
- Comparator Control
- Any other active drug or placebo/vehicle or supportive care.
- Main Outcome
- Primary outcomes 1. Proportion of progression to pneumonia 2. Proportion of progression to severe or critical COVID-19 Secondary outcomes 1. Time to test reverse transcription-polymerase chain reaction (RT-PCR) negativity 2. Proportion of patients with RCT-PCR negativity 3. Length of stay at hospital (LoS) 4. Proportion of all-cause death 5. Level of inflammatory marker such as CRP and IL-6 6. Total adverse events 7. Treatment emergent adverse events (TEAEs) 8. Withdrawal or dropout from study due to adverse events 9. Renal and liver function test Measurement time: We will assess treatment effects at Day 5 or 7 and Day 10 or 14 after treatment or the end of study. Measures of effect For dichotomous outcomes, we will measure the effect as risk ratios (RR). For continuous outcome, we will measure the effect as mean different (MD).
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- COVID-19; Herbal Medicine; Humans; Medicine, Traditional; Phytotherapy; Plants, Medicinal; SARS-CoV-2; Thailand
- Contact
- Ratree Sawangjit [email protected]
- Organisational Affiliation
- Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Thailand
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-22
- Registration Date
- 2021-08-23
- Anticipated Start Date
- 2021-08-25
- Anticipated Completion Date
- 2022-04-30
- Title Cn
- 泰式传统医学或草药治疗COVID-19的疗效与安全性：一项系统评价与Meta分析
- Title En
- Efficacy and safety of Thai traditional medicine or herbal medicine for treatment of the COVID-19: A systematic review and meta-analysis.
- Bilingual Status
- complete