Meta AnalysisID 7196
儿童和青少年哮喘急性发作中皮下注射肾上腺素联合标准一线治疗的应用：一项随机对照试验的系统评价与Meta分析
CRD42023405407
To assess the safety and efficacy of subcutaneous adrenaline in addition to standard first line treatment with inhaled/nebulized SABA and systemic steroids, compared to inhaled/nebulized SABA and systemic steroid only in
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7196
- Evidence Id
- 15754
- Core Evidence Id
- 15754
- Source Meta Analysis Id
- 7183
- Herb2 Meta Analysis Id
- HBMA007183
- Crd Id
- CRD42023405407
- Title
- The use of subcutaneous adrenaline in addition to standard first-line treatment in children and adolescents with an acute asthma exacerbation; a systemic review and meta-analysis of randomized control trials
- Review Question
- To assess the safety and efficacy of subcutaneous adrenaline in addition to standard first line treatment with inhaled/nebulized SABA and systemic steroids, compared to inhaled/nebulized SABA and systemic steroid only in children aged 18 years and under with an acute asthma exacerbation.
- Study Type Included
- We will include only randomized controlled trials in this review. We will apply no language restriction, and will undertake English translation of relevant studies if needed.
- Condition Being Studied
- This is one of a series of systematic reviews commissioned by the World Health Organization (WHO) to inform consolidated recommendations for the management of common childhood illnesses. The recommendations will update the existing guidance in the Pocket book of hospital care for children and Integrated management of childhood illness (IMCI) charts. Asthma is one of the most common chronic diseases with an estimated 262 million people affected in 2019. Asthma is a common cause of morbidity in children and adolescents. The standard first-line treatment of acute asthma exacerbations includes systemic corticosteroids and inhaled beta-agonist medications. Additional medications are added to this first-line treatment in the management of more severe asthma exacerbations with varying levels of supportive evidence. The effects of Adrenaline are variable. Its work through α1 adrenergic receptors induces vasoconstriction, blood pressure rise, and mucosal edema minimization. β1-adrenergic receptor induction, on the other hand, increases cardiac output, while stimulation of the β2-adrenergic receptor results in bronchodilation together with reduction in the release of immune mediators. Bagott et al. found that epinephrine and selective β2-agonists have similar efficacy in acute asthma. The evidence available, however, is low quality.
- Participant
- We will include children and adolescents aged 18 years and under with acute asthma exacerbation.
- Animal
- Human Disease Modelled
- Intervention
- Addition of subcutaneous Adrenaline to SABA and systemic steroid in the management of acute asthma exacerbation.
- Comparator Control
- Inhaled/nebulised SABA and systemic steroid in the management of acute asthma exacerbation.
- Main Outcome
- Morbidity (symptoms, hospitalization and school absence). Measures of effect For dichotomous data, we will report the risk ratio (RR). The mean difference (MD) or standardized mean difference (SMD) will be calculated for continuous data.
- Outcome Measure
- Additional Outcome
- • Escalation of care (ventilation/PICU admission) • Length of hospital • Adverse events • Mortality due to exacerbation • Changes in lung function (change in FEV1 and PEF). Measures of effect For dichotomous data, we will report the risk ratio (RR). The mean difference (MD) or standardized mean difference (SMD) will be calculated for continuous data.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- 3-(2-(4-azidobenzamidino)ethyl)-5-hydroxyindole; Administration, Inhalation; Adolescent; Asthma; Child; Epinephrine; Humans; Steroids
- Contact
- Khalid Mudawi [email protected]
- Organisational Affiliation
- Sidra Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada, England, Qatar, Wales
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-06
- Registration Date
- 2023-03-06
- Anticipated Start Date
- 2023-05-01
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 儿童和青少年哮喘急性发作中皮下注射肾上腺素联合标准一线治疗的应用：一项随机对照试验的系统评价与Meta分析
- Title En
- The use of subcutaneous adrenaline in addition to standard first-line treatment in children and adolescents with an acute asthma exacerbation; a systemic review and meta-analysis of randomized control trials
- Bilingual Status
- complete