Meta AnalysisID 7191
咖啡酸片治疗白细胞减少症的疗效与安全性：一项系统评价与Meta分析
CRD42023408316
P:The patients diagnosed with leukopenia (leukocyte count < 4.0×109/L) were included in the study regardless of age and gender. I:Intervention measures: Patients in the test group were treated with caffeic acid tablet
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Record Fields
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- Meta Analysis Id
- 7191
- Evidence Id
- 15749
- Core Evidence Id
- 15749
- Source Meta Analysis Id
- 7178
- Herb2 Meta Analysis Id
- HBMA007178
- Crd Id
- CRD42023408316
- Title
- Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
- Review Question
- P:The patients diagnosed with leukopenia (leukocyte count < 4.0×109/L) were included in the study regardless of age and gender. I:Intervention measures: Patients in the test group were treated with caffeic acid tablets (200-300 mg/time, 3 times/d. Dezhou Deyao Pharmaceutical Co., Ltd., approved by Chinese medicine H37020537, production batch number: 2102140503.) or caffeic acid tablets combined with conventional drugs for leukopenia. C:conventional drugs for leukopenia. The dose and duration of administration were not limited. O:The main efficacy indicators were clinical efficiency rate and changes in white blood cell count, and secondary efficacy indicators were the incidence of adverse reactions, grade III and IV myelosuppression, incidence of infection, platelet count, and neutrophil count.
- Study Type Included
- Only RCTs were included and the languages were limited to Chinese and English.
- Condition Being Studied
- The main ingredient of caffeic acid tablet is caffeic acid, also known as "3, 4-hydroxycinnamic acid" or "3, 4-dihydroxy phenyl acrylic acid", which is a phenolic compound and classified as cinnamic acid . Its molecular formula: C9H8O4, relative molecular weight: 180.16Da. It is widely found in many plant foods and herbs such as fruits, wine, coffee, olive oil, and legumes . Caffeic acid has antidepressant, antihyperglycemic, antioxidant, anticancer, antiviral, anti-inflammatory, and immunomodulatory properties. The efficacy and safety of caffeic acid tablets in the treatment of leukopenia have widely been reported in the literature, but no systematic evaluation is available. Therefore, in this study, a meta-analysis was conducted to compare the efficacy and safety of caffeic acid tablets with other medicines for leukopenia, to provide a reliable basis and evidence-based guidelines for clinical use.
- Participant
- The patients diagnosed with leukopenia (leukocyte count < 4.0×109/L) were included in the study regardless of age and gender. According to the leukocyte grading criteria set by the World Health Organization, the leukocyte counts were graded as follows: degree 0: > 4.0×109/L; degree I: 3.0 - 3.9×109/L; degree II: 2.0 - 2.9×109/L; degree III: 1.0 - 1.9×109/L; degree IV: < 1.0×109/L
- Animal
- Human Disease Modelled
- Intervention
- Intervention measures: Patients in the test group were treated with caffeic acid tablets (200-300 mg/time, 3 times/d. Dezhou Deyao Pharmaceutical Co., Ltd., approved by Chinese medicine H37020537, production batch number: 2102140503.) or caffeic acid tablets combined with conventional drugs for leukopenia.
- Comparator Control
- the control group was treated with conventional drugs for leukopenia.
- Main Outcome
- (I)The main efficacy indicators were clinical efficiency rate and changes in white blood cell count, and secondary efficacy indicators were the incidence of adverse reactions, grade III and IV myelosuppression, incidence of infection, platelet count, and neutrophil count. The clinical efficiency was indicated in the following manner: (i) significantly effective if the total leukocyte count has increased > 1.0×109/L and lasted for 2 weeks; (ii) effective if the total leukocyte count has increased between 0.5 - 1.0×109/L and lasted for 2 weeks; (iii) ineffective if the total leukocyte count has increased < 0.5×109/L. Measures of effect Meta-analysis was performed using RevMan 5.3 and Stata 17.0 software. Count data were analyzed by relative risk ratio (RR), and continuous data were analyzed by mean difference (MD) or standardized mean difference (SMD). Also, their combined effect sizes and their 95% confidence intervals (CI) were calculated. Heterogeneity was analyzed using the Q test and I² test.
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Incidence; Leukocyte Count; Leukopenia; Neutrophils; Tablets; caffeic acid
- Contact
- Hongxiu Yu [email protected]
- Organisational Affiliation
- Dali University
- Funding Source
- This research was funded by the Major Projects of Science and Technology Plan of Dali state (No. D2019NA03) and LJ Expert Workstation of Yunnan Province (No. 202005AF150013). Grant number(s) State the funder, grant or award number and the date of award Jinali
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-15
- Registration Date
- 2023-03-26
- Anticipated Start Date
- 2023-01-01
- Anticipated Completion Date
- 2023-04-14
- Title Cn
- 咖啡酸片治疗白细胞减少症的疗效与安全性：一项系统评价与Meta分析
- Title En
- Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
- Bilingual Status
- complete