Meta AnalysisID 719
左甲状腺素对妊娠期亚临床甲状腺功能减退症女性的临床益处：一项系统评价与Meta分析
CRD42022321937
(1) Population: pregnant women diagnosed with SCH, based on the 2017 ATA criteria: TSH levels above the upper limit of the pregnancy-specific reference range or (if unavailable) above 4.0mIU/L and less than 10.0mIU/L; (2
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 719
- Evidence Id
- 9277
- Core Evidence Id
- 9277
- Source Meta Analysis Id
- 696
- Herb2 Meta Analysis Id
- HBMA000696
- Crd Id
- CRD42022321937
- Title
- Clinical benefits of levothyroxine in women with subclinical hypothyroidism during pregnancy : a systematic review and meta-analysis
- Review Question
- (1) Population: pregnant women diagnosed with SCH, based on the 2017 ATA criteria: TSH levels above the upper limit of the pregnancy-specific reference range or (if unavailable) above 4.0mIU/L and less than 10.0mIU/L; (2) Intervention: thyroxine (including levothyroxine, thyroxine supplementation); (3) Comparison: placebo or no treatment; (4) Outcomes: pregnancy, neonatal, and childhood outcomes; (5) Study design: randomized controlled trial and cohort study.
- Study Type Included
- Study design: randomized controlled trial and cohort study
- Condition Being Studied
- Subclinical hypothyroidism is a common thyroid disorder during pregnancy, which is defined as the thyroid stimulating hormone value greater than the upper limit of the reference range with a normal free thyroxine. The prevalence of subclinical hypothyroidism during pregnancy is range from 2% to 5% depending on diagnostic criteria, TPOAb status, ethnicity and iodine intake. There have been systematic reviews on the clinical benefits of LT4 therapy in pregnant women with SCH, but the results have been inconsistent, which may be related to the different upper cutoff values of TSH used for the diagnosis of SCH.
- Participant
- Population: pregnant women diagnosed with SCH, based on the 2017 ATA criteria: TSH levels above the upper limit of the pregnancy-specific reference range or (if unavailable) above 4.0mIU/L and less than 10.0mIU/L
- Animal
- Human Disease Modelled
- Intervention
- Intervention: thyroxine (including levothyroxine, thyroxine supplementation)
- Comparator Control
- Comparison: placebo or no treatment
- Main Outcome
- childhood IQ, physical and neurodevelopment, preterm delivery, miscarriage, gestational hypertension, gestational diabetes
- Outcome Measure
- Additional Outcome
- placental abruption, fetal growth restriction, fetal distress, pregnant women anemia, postpartum hemorrhage, premature rupture of membranes, preeclampsia, small for gestational age, low birth weight, neonatal admission, neonatal death, respiratory distress syndrome
- Study Method
- Systematic review
- Keyword
- Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Outcome; Thyroxine
- Contact
- Miao Zhang [email protected]
- Organisational Affiliation
- Department of Pharmacy, West China Second University Hospital, Sichuan University
- Funding Source
- National Natural Science Foundation; Science and Technology Plan Project of Sichuan Province
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-30
- Registration Date
- 2022-04-30
- Anticipated Start Date
- 2022-02-01
- Anticipated Completion Date
- 2022-07-01
- Title Cn
- 左甲状腺素对妊娠期亚临床甲状腺功能减退症女性的临床益处：一项系统评价与Meta分析
- Title En
- Clinical benefits of levothyroxine in women with subclinical hypothyroidism during pregnancy : a systematic review and meta-analysis
- Bilingual Status
- complete