Meta AnalysisID 7186
营养补充剂对多囊卵巢综合征女性的改善作用：一项系统评价与网状Meta分析
CRD42023483534
Nutritional supplements have been widely used in polycystic ovary syndrome (PCOS) patients. This study aimed to compare the effects of nutritional supplements on Endocrine and Metabolic States, inflammatory and oxidative
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Record Fields
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- Meta Analysis Id
- 7186
- Evidence Id
- 15744
- Core Evidence Id
- 15744
- Source Meta Analysis Id
- 7173
- Herb2 Meta Analysis Id
- HBMA007173
- Crd Id
- CRD42023483534
- Title
- The effectiveness of nutrition supplements in improving in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
- Review Question
- Nutritional supplements have been widely used in polycystic ovary syndrome (PCOS) patients. This study aimed to compare the effects of nutritional supplements on Endocrine and Metabolic States, inflammatory and oxidative markers, reproductive hormones, anthropometric markers, in patients with PCOS using network meta-analysis.
- Study Type Included
- Inclusion: Randomiszed control trial(RCT) Exclusion criteria: studies are cohort studies, review articles, descriptive studies, opinion articles.
- Condition Being Studied
- Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. 4–10% of reproductive-age women are predicted to have PCOS worldwide. The pathophysiology of PCOS is chiefly concerned with hormonal imbalance, chronic low-grade inflammation, insulin resistance, and hyperandrogenism, which impair folliculogenesis and increase the risk of related comorbidities. Several clinical studies have demonstrated the potency of nutritional supplements, nutrition therapy is effective intervention in decreasing inflammation and enhancing endocrine and Metabolic States or improving reproductive hormones. However, it is not clear what type of nutrition therapies are optimal for patients with PCOS. Therefore, we aimed to identify the most appropriate nutrition therapies for PCOS patients.
- Participant
- Inclusion: Women of reproductive age (18-49 years old) with polycystic ovary syndrome. Exclusion: Women who were pregnant or intended to be pregnant.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Patients in the intervention group received at least one of the following nutritional supplements (in any form, dose, or duration): Magnesium, Selenium, Chromium, Calcium, Zinc, Probiotic, Synbiotic, Vitamin, Coenzyme Q10, Cinnamon, Omega-3, Carnitine, Melatonin, Folate, Alpha lipoic acid, Carnitine, Soy isoflavones, Dietary soy, or a combination of these supplements.
- Comparator Control
- Inclusion: Received either placebo or conventional treatment. If patients in both intervention groups and control groups received adjuvant therapy at the same time, the adjuvant therapy should be the same.
- Main Outcome
- The main outcome were Endocrine and Metabolic States[fasting plasma glucose (FPG), eostatic Model AssessmenHomt of Insulin Resistance (HOMA-IR), and Fasting Blood Sugar (FBS), Insulin (ins), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)], inflammatory and oxidative markers[Hs-C-reactive protein (CRP), plasma nitric oxide (NO), total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA)], reproductive hormones[total testosterone (TT), sex hormone-binding globulin (SHBG), and dehydroepiandrosterone (DHEAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone]. Measures of effect The mean difference (MD) was calculated for continuous data to determine the effect size. A pooled odds ratio (OR) was calculated for categorical data. All date are expressed with 95% confidence interval(Cl).
- Outcome Measure
- Additional Outcome
- Body mass index (BMI)
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Jian-chang He [email protected]
- Organisational Affiliation
- The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, China.
- Funding Source
- The Construction of research platform for early clinical trials of innovative drugs from Yunnan Province Science and Technology Department (No. 202302AA310007)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-11-17
- Registration Date
- 2023-11-27
- Anticipated Start Date
- 2023-11-01
- Anticipated Completion Date
- 2024-02-15
- Title Cn
- 营养补充剂对多囊卵巢综合征女性的改善作用：一项系统评价与网状Meta分析
- Title En
- The effectiveness of nutrition supplements in improving in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
- Bilingual Status
- complete