Meta AnalysisID 7182
天然产物对多囊卵巢综合征女性代谢及内分泌状态疗效的研究
CRD42023424883
Can natural products improve the metabolic and endocrine status of PCOS patients?
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Record Fields
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- Meta Analysis Id
- 7182
- Evidence Id
- 15740
- Core Evidence Id
- 15740
- Source Meta Analysis Id
- 7169
- Herb2 Meta Analysis Id
- HBMA007169
- Crd Id
- CRD42023424883
- Title
- Investigating the efficacy of natural products on metabolism and on endocrine status in women with PCOS
- Review Question
- Can natural products improve the metabolic and endocrine status of PCOS patients?
- Study Type Included
- Inclusion criteria: we are planning to include RCT studies in our research work. Exclusion criteria: we are planning to exclude reviews, meta-analyses, letters, case series, case reports.
- Condition Being Studied
- Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders, characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries. Metformin is the first-line drug in PCOS women with insulin resistance (IR) and type-2 diabetes mellitus to improve their metabolic and endocrine status in the past 30 years, however, it has several side effects as well. The most serious is lactic acidosis, as it can lead to metabolic acidosis, which can eventually lead to hypotension and hypothermia. Various natural products can increase estrogen levels and antiandrogenic activity; they can reduce LH-, insulin-, testosterone-, cholesterol-, and trigliceride levels; they can optimize body mass index and regulate menstrual characteristics. Improving the metabolic and hormonal parameters of PCOS patients can lead to better health and quality of life, higher pregnancy rate and more women with PCOS can have a child. Our aim is to compare the efficacy of natural products to short-term metformin (8-24 week) or placebo (6-24 week) in women with PCOS. Our vision is that less metformin might be sufficient to improve the metabolic and endocrine status in women with PCOS if natural products are regularly used in addition to metformin.
- Participant
- women with PCOS
- Animal
- Human Disease Modelled
- Intervention
- Natural products [foeniculum vulgare (fennel), cimicifuga racemosa (actaea racemose/black chosh), grifola frondosa (maitake), vitex agnus-castus (chasteberry), berberine, mentha spicata (spearmint), Cinnamon (cinnamomum), origanum majorana (marjoram), trigonella foenum-graecum (fenugreek), glycyrrhiza glabra (licorice), glycyne max (soy), punica granatum (pomegranate), salvia oficinalis (sage), panax (ginseng), stachys lavandulifolia (wood betony), linum usitatissimum (flax), paeonia lactiflora (chinese pheony), tribulus terrestris (puncture vine), curcuma (turmeric), omega-3 fatty acid with or without vitamin E, vitamin D, myo-inositol with or without folic acid, D-chiro inositol].
- Comparator Control
- Short-term metformin or placebo
- Main Outcome
- Primary outcomes: body mass index; dietary intakes (carbohydrate-, protein-, total fat); glucose-, insulin level; Homeostatic Model Assessment of Insulin Resistance (HOMA-IR); total cholesterol-, triglyceride-, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL) level. Secondary outcomes: Should data volume permit, the following outcomes will be analyzed as well physical activity; waist to hip ratio (WHR); menstrual charachteristics; blood pressure; area under the insulin curve; area under the glucose curve; total testosterone-, free testosterone-, dehydroepiandrosterone sulphate (DHEAS)-, sex hormone-binding globulin (SHBG)- and androstendione level. Measures of effect Odds ratios (OR) for dichotomous outcomes, Weighted- or standardized mean difference (WMD or SMD) for continuous ones.
- Outcome Measure
- Additional Outcome
- None. Measures of effect None.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Biochemical Phenomena; Biological Products; Female; Humans; Insulin Resistance; Patients; Polycystic Ovary Syndrome
- Contact
- Rita Zsuzsanna Vajna [email protected]
- Organisational Affiliation
- Semmelweis University Centre for Translational Medicine www.tm-centre.org
- Funding Source
- None. Grant number(s) State the funder, grant or award number and the date of award None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-08
- Registration Date
- 2023-05-19
- Anticipated Start Date
- 2023-05-09
- Anticipated Completion Date
- 2023-08-01
- Title Cn
- 天然产物对多囊卵巢综合征女性代谢及内分泌状态疗效的研究
- Title En
- Investigating the efficacy of natural products on metabolism and on endocrine status in women with PCOS
- Bilingual Status
- complete