Meta AnalysisID 7176
提高特发性复发性流产女性活产率的干预措施：一项系统评价与网状Meta分析
CRD42023455668
To systematically review and summarize current knowledge about which therapeutic interventions should be offered to couples with idiopathic recurrent pregnancy loss to increase live birth rate?
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Record Fields
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- Meta Analysis Id
- 7176
- Evidence Id
- 15734
- Core Evidence Id
- 15734
- Source Meta Analysis Id
- 7163
- Herb2 Meta Analysis Id
- HBMA007163
- Crd Id
- CRD42023455668
- Title
- Interventions to improve live birth rate in women with idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis
- Review Question
- To systematically review and summarize current knowledge about which therapeutic interventions should be offered to couples with idiopathic recurrent pregnancy loss to increase live birth rate?
- Study Type Included
- We will include published and/or registered with results randomised controlled trials (RCTs) assessing the efficacy and safety of any pharmacological intervention for idiopathic recurrent pregnancy loss. We will exclude cross-over trials, due to inappropriateness of this study design in this context. We will impose no restrictions on the number of participants recruited, the number of recruitment centres, regional area, or publication language. Unpublished studies (i.e., conference proceedings and poster or oral presentations) will also be included if enough data are present to adequately synthesise the conclusions.
- Condition Being Studied
- Recurrent pregnancy loss is defined as two or more pregnancy losses (ESHRE, update in 2022) before the fetus reached viability from the time of conception until 24 weeks of gestation and it affects around 1-2% of couples. In almost 50% of cases, the causes are idiopathic (idiopathic recurrent pregnancy loss). To date, no systematic review and network meta-analysis of randomized controlled trials comparing the effectiveness of therapeutic interventions for women with idiopathic recurrent pregnancy loss, and in accordance with the new ESHRE (2002) definition of recurrent pregnancy loss, has been designed.
- Participant
- The study will enrol women in reproductive age, with more than 18 years, diagnosed with idiopathic recurrent pregnancy loss after proper exclusion of all the current known established causes/risk factors, including advanced maternal age, parental chromosomal abnormalities, uterine anatomical disorders, inherited and/or acquired thrombophilia, thyroid disorders, environmental factors, among others. Exclusion criteria will comprise age <18yrs, recurrent pregnancy loss of known cause, and actual pregnancy.
- Animal
- Human Disease Modelled
- Intervention
- Treatment (intervention): acetylsalicylic acid, low-molecular-weight heparin, progesterone, corticosteroids, intravenous immunoglobulin, leukocyte immune therapy, pre-implantation genetic screening, hydroxychloroquine, human chorionic gonadotrophin, granulocyte colony-stimulating factor, intralipid therapy, levothyroxine, folic acid, multivitamin, clomiphene citrate, sitagliptin, metformin, vitamin D.
- Comparator Control
- Placebo or No treatment. We plan to compare any type of pharmacological intervention with any comparator arm, such as: 1) placebo intervention, 2) no intervention, 3) non-pharmacological intervention, or 4) a combination of the above.
- Main Outcome
- The primary aim of this systematic review was to compare the efficacy therapeutic interventions for women with idiopathic recurrent pregnancy loss. Main outcomes: Live Birth Rate %; Miscarriage Rate % Measures of effect The primary outcome was live birth after the 22nd gestational week. Measures of the association between intervention exposure and the outcome: relative risk (RR) or risk ratio is the ratio of the probability of an outcome in the exposed group (intervention) to the probability of an outcome in the unexposed group (placebo/no treatment). In the meta-analysis the effect estimate will be expressed as a risk ratio (RR) with 95% confidence interval.
- Outcome Measure
- Additional Outcome
- Secondary outcomes were complications or side effects of the intervention. Measures of effect Measures of the association between intervention exposure and the outcome: relative risk (RR) or risk ratio is the ratio of the probability of an outcome in the exposed group (intervention) to the probability of an outcome in the unexposed group (placebo/no treatment) In the meta-analysis the effect estimate will be expressed as a risk ratio (RR) with 95% confidence interval.
- Study Method
- Epidemiologic, Intervention, Meta-analysis, Network meta-analysis, Systematic review
- Keyword
- Abortion, Habitual; Birth Rate; Female; Humans; Live Birth; Network Meta-Analysis; Pregnancy
- Contact
- Jorge Lima [email protected]
- Organisational Affiliation
- Immunology, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa; Lisboa, Portugal. Department of Obstetrics and Gynecology, Hospital da Luz Lisboa, Portugal.
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Portugal
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-04
- Registration Date
- 2023-09-15
- Anticipated Start Date
- 2023-07-12
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 提高特发性复发性流产女性活产率的干预措施：一项系统评价与网状Meta分析
- Title En
- Interventions to improve live birth rate in women with idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis
- Bilingual Status
- complete