Meta AnalysisID 7173
桥本甲状腺炎的临床比较疗效与治疗策略：一项系统评价与网状Meta分析
CRD42023449705
Thyroid disease was called 'Yingbing' in ancient China, which has a long history treated with herbal medicine. Modern pharmacological experiments and clinical trials show that herbs have unique advantages and curative ef
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Record Fields
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- Meta Analysis Id
- 7173
- Evidence Id
- 15731
- Core Evidence Id
- 15731
- Source Meta Analysis Id
- 7160
- Herb2 Meta Analysis Id
- HBMA007160
- Crd Id
- CRD42023449705
- Title
- Clinical Comparative Efficacy and Therapeutic Strategies for the Hashimoto's Thyroiditis: a Systematic Review and Network Meta-analysis.
- Review Question
- Thyroid disease was called 'Yingbing' in ancient China, which has a long history treated with herbal medicine. Modern pharmacological experiments and clinical trials show that herbs have unique advantages and curative effects in the treatment of thyroid diseases. However, the effect of different intervention strategies, such as the combination of herbal medicine with vitamin D, levothyroxine, or selenium preparation et. al, has not been confirmed. Therefore, we conducted a network meta-analysis of randomized controlled trials. The network meta-analysis can systematically evaluate the impact of different intervention strategies on the main thyroid outcome indicators of HT.
- Study Type Included
- Study type: randomized controlled trial. We excluded duplicate publications, articles with a lack of sufficient data research, research where the full text was not available, interventions with non-drug therapies, research in which baseline characteristics between the experimental and control groups were inconsistent, comparative studies of different doses of the same drug, and studies in which the control groups were follow-up observation.
- Condition Being Studied
- Hashimoto’s thyroiditis (HT) is an autoimmune disease that destroys thyroid cells by cell and elevating thyroid autoantibody levels at an early stage, which has gradually become the main cause of hypothyroidism. The incidence of HT worldwide is serious, about 0.3–1.5 cases per 1000 people, which is one of the most common chronic autoimmune thyroiditis. The disease is more likely to affect women than men, most often in middle-aged women, and the risk of its development increases with age. Moreover, patients with HT are more likely to be affected by cardiovascular diseases and malignant neoplasms. In addition, hypothyroidism affects all organic systems, but the most common symptoms that burden HT patients are weight gain, constipation, lethargy, fatigue, cold intolerance, hair loss et. al. Many recent studies evaluated connection of thyroid autoantibodies with other disorders in euthyroid HT patients, showing that there were lower life quality scores in euthyroid HT patients with high thyroid antibodies levels. Therefore, HT not only harms the health, but also brings serious economic burden.
- Participant
- Object of study: patients with HT as defined by the standardized diagnostic manuals or the international classification of the disease, with no restrictions on age, gender, and course of disease.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion criteria Intervention: the treatment group includes herbal medicine, vitamin D, levothyroxine, LT4, selenium preparation, myoinositol, prednisone, and can also be combined with each other on these bases. The control group is placebo or conventional treatment. Exclusion criteria We excluded duplicate publications, articles with a lack of sufficient data research, research where the full text was not available, interventions with non-drug therapies, research in which baseline characteristics between the experimental and control groups were inconsistent, comparative studies of different doses of the same drug, and studies in which the control groups were follow-up observation.
- Comparator Control
- Nine different treatment regimen interventions, including VD, Se, LT-4, Se+LT-4, HM, placebo+LT-4, HM+LT-4, Se+myolnositol, Se+VD, HM+Se, Mannan peptide, LT-4+prednisone, Methimazole, Methimazole+HM, Tapazole+Propranolol and placebo.
- Main Outcome
- Outcome indicators: TPOAb, TgAb.
- Outcome Measure
- Additional Outcome
- Additional outcome: TSH, FT3 and FT4.
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Hashimoto Disease; Humans; Plants, Medicinal; Randomized Controlled Trials as Topic; Selenium; Thyroxine; Vitamin D; Vitamins
- Contact
- Jinli Luo [email protected]
- Organisational Affiliation
- Beijing University of Chinese Medicine
- Funding Source
- This study was supported by grants from the Clinical Research Center Construction Project of Guang’anmen Hospital, CACMS (No. 2022LYJSZX15) and Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No: ZYYCXTD-D-202001)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-29
- Registration Date
- 2023-08-08
- Anticipated Start Date
- 2023-06-01
- Anticipated Completion Date
- 2023-08-31
- Title Cn
- 桥本甲状腺炎的临床比较疗效与治疗策略：一项系统评价与网状Meta分析
- Title En
- Clinical Comparative Efficacy and Therapeutic Strategies for the Hashimoto's Thyroiditis: a Systematic Review and Network Meta-analysis.
- Bilingual Status
- complete