Meta AnalysisID 7171
左甲状腺素对亚临床甲状腺功能减退症和甲状腺过氧化物酶抗体阳性的复发性流产女性妊娠结局的影响：一项系统评价与Meta分析
CRD42023434011
Considering these controversial reports, we perform a meta-analysis based on previously published studies reporting the effect of levothyroxine on the pregnancy outcomes in RPL women with SCH or TPOAb+.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7171
- Evidence Id
- 15729
- Core Evidence Id
- 15729
- Source Meta Analysis Id
- 7158
- Herb2 Meta Analysis Id
- HBMA007158
- Crd Id
- CRD42023434011
- Title
- Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis
- Review Question
- Considering these controversial reports, we perform a meta-analysis based on previously published studies reporting the effect of levothyroxine on the pregnancy outcomes in RPL women with SCH or TPOAb+.
- Study Type Included
- cohort studies or randomized controlled trials
- Condition Being Studied
- Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies according to the guideline of European Society of Human Reproduction and Embryology (ESHRE)
- Participant
- RPL women with SCH or TPOAb+
- Animal
- Human Disease Modelled
- Intervention
- comparing pregnancy outcomes between intervention group and control group (levothyroxine-treated women vs. untreated women/placebo-treated women/women with basic treatment; basic treatment + levothyroxine-treated women vs. women with basic treatment)
- Comparator Control
- levothyroxine-treated women vs. untreated women/placebo-treated women/women with basic treatment; basic treatment + levothyroxine-treated women vs. women with basic treatment
- Main Outcome
- The outcomes assessed in this meta-analysis were pregnancy outcomes and thyroid function. Pregnancy outcomes included pregnancy rate, live birth rate, premature delivery (at < 37 weeks), miscarriage rate, premature rupture of membranes (PROM), fetal growth restriction, ectopic pregnancy, 1 min Apgar, 5 min Apgar, birth weight (g), and birth height (cm).
- Outcome Measure
- Additional Outcome
- Thyroid function was assessed through TSH, free thyroxine (FT4), thyroid peroxidase (TPO), and thyroid peroxidase antibody (anti-TPO).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Outcome; Thyroxine
- Contact
- Lili Tao [email protected]
- Organisational Affiliation
- Department of Gynaecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-09
- Registration Date
- 2023-06-20
- Anticipated Start Date
- 2022-06-24
- Anticipated Completion Date
- 2023-07-24
- Title Cn
- 左甲状腺素对亚临床甲状腺功能减退症和甲状腺过氧化物酶抗体阳性的复发性流产女性妊娠结局的影响：一项系统评价与Meta分析
- Title En
- Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis
- Bilingual Status
- complete