Meta AnalysisID 7155
雌激素和孕激素对健康子宫内膜的分子和遗传调控：系统评价
CRD42023429752
Which genes and molecules are regulated by estrogens and progesterone in the healthy endometrium?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7155
- Evidence Id
- 15713
- Core Evidence Id
- 15713
- Source Meta Analysis Id
- 7139
- Herb2 Meta Analysis Id
- HBMA007139
- Crd Id
- CRD42023429752
- Title
- Molecular and genetic regulation of the healthy endometrium by estrogens and progesterone: A systematic review
- Review Question
- Which genes and molecules are regulated by estrogens and progesterone in the healthy endometrium?
- Study Type Included
- This review includes all the studies found in the searches
- Condition Being Studied
- Molecular and genetic expression in endometrial samples or cell cultures from healthy endometrium
- Participant
- Inclusion: Healthy women (without any systemic and gynecological pathologies) at reproductive age. Exclusion: Women with any type of systemic or gynecological pathologies (i.e. cancer, adenomyosis, endometriosis, fibroids, myomas, cardiovascular diseases). Therefore, all studies in which endometrial tissue samples are obtained from patients with any systemic or gynecological disease are excluded, as well as those using purchased cell lines which were obtained from patients with diseases (e.g. Ishikawa cells).
- Animal
- Human Disease Modelled
- Intervention
- This review aims to characterize the molecular and genetic regulation of the healthy endometrium, giving a complete list of genes that are playing a key role in menstrual cycle, endometrial progression and implantation and pregnancy, and how these are regulated by ovarian steroids. For this purpose, we evaluated those studies that have demonstrated significant regulation of gene, protein or different molecules expression using molecular biology techiniques, both basic ones, such as Western blot and qPCR, as well as high-throughput ones.
- Comparator Control
- Not applicable
- Main Outcome
- Studies evidencing genetic and protein expression changes in healthy endometrium by estrogens and progesterone exposure. Measures of effect The significance of the differences in molecular and gene expression observed was assessed by attending to p-values or adjusted p-values. Moreover, we evaluated the magnitude and the type of the change (i.e. if these molecules are up- or down- regulated and their fold change).
- Outcome Measure
- Additional Outcome
- Not applicable.
- Study Method
- Systematic review
- Keyword
- Endometrium; Estrogens; Female; Gene Expression Regulation; Humans; Progesterone
- Contact
- Patricia Diaz-Gimeno [email protected]
- Organisational Affiliation
- IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain https://www.ivi-rmainnovation.com/es/centros-investigacion/fundacion-ivi/
- Funding Source
- This research is funded by IVIRMA Global Research Alliance, IVI Foundation, Instituto de Salud Carlos III and Ministery of Spain. Grant number(s) State the funder, grant or award number and the date of award Patricia Diaz-Gimeno: Miguel Servet (CP20/00118) program; Diana Marti-Garcia: (FPU19/03247); Antonio Parraga-Leo: (FPU18/01777) ;Pablo Garcia-Acero: (FI20/00085) ; Maria Salvaleda-Mateu: (FPU21/02789) ;Patricia Sebastian-Leon: (CD21/00132).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Spain
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-14
- Registration Date
- 2023-07-26
- Anticipated Start Date
- 2021-01-20
- Anticipated Completion Date
- 2023-12-01
- Title Cn
- 雌激素和孕激素对健康子宫内膜的分子和遗传调控：系统评价
- Title En
- Molecular and genetic regulation of the healthy endometrium by estrogens and progesterone: A systematic review
- Bilingual Status
- complete