Meta AnalysisID 7153
脱氢表雄酮对体外受精的影响：系统评价和Meta分析
CRD42023428885
To evaluate the effectiveness and safety of dehydroepiandrosterone (DHEA) supplementation in the in vitro fertilization (IVF) outcomes and endometrial receptivity.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7153
- Evidence Id
- 15711
- Core Evidence Id
- 15711
- Source Meta Analysis Id
- 7137
- Herb2 Meta Analysis Id
- HBMA007137
- Crd Id
- CRD42023428885
- Title
- Effect of dehydroepiandrosterone for in vitro fertilisation: a systematic review and meta-analysis
- Review Question
- To evaluate the effectiveness and safety of dehydroepiandrosterone (DHEA) supplementation in the in vitro fertilization (IVF) outcomes and endometrial receptivity.
- Study Type Included
- The randomised controlled trials (RCTs) and half- RCTs were eligible for inclusion.
- Condition Being Studied
- Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid. In the past decades, several studies aimed to prove the benefit of DHEA supplementation during in vitro fertilization (IVF) cycles, but its role has yet to be determined. Therefore, we aimed to compile data from clinical studies with the use of a rigorous ethodology to offer a better understanding of the impact of DHEA addition in the fertility outcomes and endometrial receptivity in IVF cycles.
- Participant
- Women undergoing in vitro fertilisation (IVF) or intra-cytoplasmic sperm injection (ICSI), or both.
- Animal
- Human Disease Modelled
- Intervention
- The intervention is cotreatment with DHEA in the previous menstrual cycle or during COS.
- Comparator Control
- The control group will receive conventional COS without DHEA supplementation.
- Main Outcome
- a) Live birth rate, defined as pregnancy beyond 24 weeks' gestation; b) Clinical pregnancy rate (per cycle) as the presence of a gestational sac on transvaginal ultrasound; c) Ongoing pregnancy rate (per cycle) as a pregnancy beyond 12 weeks' gestation; d) Miscarriage rate (per clinical pregnancy) as fetal loss before the 20th week of gestation; e) Endometrial thickness, pattern and volume.
- Outcome Measure
- Additional Outcome
- a) Total oocytes (per cycle) as the total number of oocytes retrieved at pick-up; b) Mature oocytes (per cycle) as the number of mature oocytes obtained; c) Total embryos (per cycle) as the total number of viable embryos available to transfer; d) Serum estradiol (E2) in HCG day; e) helical arterial blood flow index including resistive index (RI), pulse index (PI), peak systolic velocity/end-diastolic blood velocity (S/D); f) Adverse effects.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Dehydroepiandrosterone; Dietary Supplements; Endometrium; Female; Fertilization in Vitro; Humans
- Contact
- LING HUANG [email protected]
- Organisational Affiliation
- BEIJING UNIVERSITY OF CHINESE MEDICINE
- Funding Source
- National Natural Science Foundation of China
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-23
- Registration Date
- 2023-06-03
- Anticipated Start Date
- 2023-05-23
- Anticipated Completion Date
- 2023-07-31
- Title Cn
- 脱氢表雄酮对体外受精的影响：系统评价和Meta分析
- Title En
- Effect of dehydroepiandrosterone for in vitro fertilisation: a systematic review and meta-analysis
- Bilingual Status
- complete