Meta AnalysisID 7142
母乳中黄酮类化合物与过敏患病率关联的系统评价
CRD42023416515
-How flavonoid level in breast milk affect inflammatory cytokines? -How flavonoid level in breast milk could prevent allergies? -What is the difference between human milk flavonoid and dietary flavonoid?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7142
- Evidence Id
- 15700
- Core Evidence Id
- 15700
- Source Meta Analysis Id
- 7279
- Herb2 Meta Analysis Id
- HBMA007279
- Crd Id
- CRD42023416515
- Title
- A SYSTEMATIC REVIEW ON THE ASSOCIATION OF HUMAN MILK FLAVONOIDS WITH ALLERGY PREVALANCES
- Review Question
- -How flavonoid level in breast milk affect inflammatory cytokines? -How flavonoid level in breast milk could prevent allergies? -What is the difference between human milk flavonoid and dietary flavonoid?
- Study Type Included
- The article used for the review must be in English Language, published between 2012-2023 and type of article must be research article.
- Condition Being Studied
- The study will provide useful and valuable information on the association of human milk flavonoids with allergy prevalence among infants and how it affects inflammatory cytokine.
- Participant
- Breastfeed mother Infants
- Animal
- Human Disease Modelled
- Intervention
- The presence of flavonoids in human milk only has been determined by a few studies and has been done with respect to isoflavones, especially in soy milk.
- Comparator Control
- Flavonoid in human milk and flavonoid in dietary are being compared based on their bioavailability.
- Main Outcome
- i. Types and levels of flavonoids in breast milk. ii. Effects of flavonoids in breast milk on inflammatory cytokines. iii. Differences between dietary flavonoid and breast milk flavonoids. Measures of effect i. There are 6 different types of flavonoid in human milk such as isoflavonoid, flavanone, flavanol, flavonol, flavone, anthocyanidin. ii. Flavonoids such as luteolin, apigenin, and fisetin significantly reduced the production of IL-4 and IL-13 by peripheral blood basophils activated by an allergen or anti-IgE antibodies. iii.The bioavailability of flavonoids could be improved via the consumption of fat and increases their intestinal absorption through increased bile salts secretion which increases micellar incorporation of flavonoids. Meanwhile, flavonoid availability will decrease due to protein consumption, reducing antioxidant effectiveness and protein digestibility.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Systematic review
- Keyword
- Cytokines; Female; Flavonoids; Humans; Milk Hypersensitivity; Milk, Human; Polyphenols
- Contact
- WAN HAZWANI WAN ROZAIMAN [email protected]
- Organisational Affiliation
- UNIVERSITI TEKNOLOGI MARA fsg.uitm.edu.my
- Funding Source
- UiTM DUCS grant 2020 Grant number(s) State the funder, grant or award number and the date of award 600-UiTMSEL(PI.5/4)(009/2020)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Malaysia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-20
- Registration Date
- 2023-05-31
- Anticipated Start Date
- 2022-10-31
- Anticipated Completion Date
- 2023-07-10
- Title Cn
- 母乳中黄酮类化合物与过敏患病率关联的系统评价
- Title En
- A SYSTEMATIC REVIEW ON THE ASSOCIATION OF HUMAN MILK FLAVONOIDS WITH ALLERGY PREVALANCES
- Bilingual Status
- complete