Meta AnalysisID 714
色氨酸-犬尿氨酸通路在母体、胎儿及胎盘健康与妊娠结局中的作用：一项系统评价
CRD42021273120
What is the role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome?
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Record Fields
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- Meta Analysis Id
- 714
- Evidence Id
- 9272
- Core Evidence Id
- 9272
- Source Meta Analysis Id
- 704
- Herb2 Meta Analysis Id
- HBMA000704
- Crd Id
- CRD42021273120
- Title
- The role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome: a systematic review
- Review Question
- What is the role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome?
- Study Type Included
- We will include human experimental (e.g. randomised controlled trials, in vivo, in vitro and ex vivo studies) and observational studies (e.g. cohort studies, case-control studies and cross-sectional studies). In contrast, we will exclude animal studies, case reports, case series, conference abstracts, letters, editorials, opinion papers and reviews. However, we will use animal studies in the introduction and in the discussion to substantiate our results. In addition, we will screen the reference lists of reviews for additional eligible studies previously missed by the search.
- Condition Being Studied
- Pregnant women without any restriction regarding study setting (such as first-line and tertiary care treatment).
- Participant
- Inclusion: Pregnant women. Exclusion: Non-pregnant women.
- Animal
- Human Disease Modelled
- Intervention
- We will focus on metabolites involved in the tryptophan and kynurenine pathway, such as: 1) Tryptophan 2) N-formyl kynurenine 3) Kynurenine 4) Kynurenic acid 5) 3-Hydroxykynurenine 6) Xanthurenic acid 7) 3-Hydroxyanthranilic acid (3-HAA) 8) α-amino-β-carboxymuconate-ε-semialdehyde (ACMS) 9) Quinolinic acid 10) Picolinic acid 11) 3-Hydroxyanthranilic acid 12) Nicotinamide-Adenine-Dinucleotide (NAD+)
- Comparator Control
- As there are no clinical cut off points, we will focus on differences in levels of metabolites involved in the tryptophan and kynurenine pathway and on different responses to metabolites involved in the tryptophan and kynurenine pathway.
- Main Outcome
- 1) Foetal health: e.g. embryonic and foetal growth and development 2) Maternal health: pregnancy complications such as pregnancy induced hypertensive disorders (e.g. preeclampsia) and gestational diabetes 3) Placental health: e.g. placental (in)sufficiency, weight, (mal)perfusion, vascular function and oxidative damage 4) Pregnancy outcome: e.g. miscarriages, preterm birth, small for gestational age (SGA), low birthweight and congenital malformations Measures of effect Depending on the study design and the measured exposures and outcomes, we will report betas, mean differences, relative risks and odds ratios.
- Outcome Measure
- Additional Outcome
- None. Measures of effect
- Study Method
- Systematic review
- Keyword
- Female; Humans; Kynurenine; Placenta; Pregnancy; Pregnancy Outcome; Tryptophan
- Contact
- Sofie van Zundert [email protected]
- Organisational Affiliation
- Erasmus MC, University Medical Centre, Rotterdam, the Netherlands www.erasmusmc.nl
- Funding Source
- Erasmus MC, University Medical Centre, Rotterdam, the Netherlands
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Netherlands
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-11
- Registration Date
- 2021-09-11
- Anticipated Start Date
- 2021-05-10
- Anticipated Completion Date
- 2021-12-10
- Title Cn
- 色氨酸-犬尿氨酸通路在母体、胎儿及胎盘健康与妊娠结局中的作用：一项系统评价
- Title En
- The role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome: a systematic review
- Bilingual Status
- complete