Meta AnalysisID 7131
美洲大蠊提取物在胃溃疡动物模型中的有效性及其机制：一项系统评价与Meta分析
CRD42023469403
Is Periplaneta Americana L. extract effective in animal models of gastric ulcer? And how does it work? Context and rationale Gastric ulcer (GU) is a prevalent chronic gastrointestinal disorder that poses a significant th
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Record Fields
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- Meta Analysis Id
- 7131
- Evidence Id
- 15689
- Core Evidence Id
- 15689
- Source Meta Analysis Id
- 7118
- Herb2 Meta Analysis Id
- HBMA007118
- Crd Id
- CRD42023469403
- Title
- Effectiveness and mechanism of Periplaneta americana L. extract in animal models of gastric ulcer: A systematic review and meta-analysis
- Review Question
- Is Periplaneta Americana L. extract effective in animal models of gastric ulcer? And how does it work? Context and rationale Gastric ulcer (GU) is a prevalent chronic gastrointestinal disorder that poses a significant threat to human health. It affects a substantial proportion of the global population, with an estimated prevalence ranging from 5% to 10%. Notably, the United States alone reports an annual incidence of approximately 500, 000 GU cases, incurring a staggering financial burden of up to 10 billion dollars for therapeutic interventions. Clinically, the most commonly encountered manifestations encompass epigastric pain, abdominal distension, eructation, and acid regurgitation, among others. Scholarly investigations have consistently underscored the predilection of gastric ulcers for regions within the gastric lumen that are subjected to the corrosive effects of gastric acid and proteolytic enzymes, with the lesser curvature serving as the most frequently affected site, albeit acknowledging the potential involvement of any segment spanning from the pylorus to the cardia. Under physiological circumstances, the gastric mucosa exhibits remarkable resilience against the deleterious impact of high concentrations of hydrochloric acid, refluxed bile acids, alcohol, as well as foodstuffs characterized by disparate thermal and osmotic properties. However, perturbations characterized by escalated gastric acid or proteolytic enzyme levels, coupled with compromised mucosal defense mechanisms, precipitate local tissue injury within the gastric mucosa, culminating in the formation of ulcerative lesions. The extract derived from Periplaneta americana L. (American cockroach) and its modern formulation, Kangfuxin liquid, have demonstrated notable anti-inflammatory, immunomodulatory, and ulcer-healing properties. Therefore, they have been widely employed in many diseases, such as gastrointestinal ulcers and cutaneous wounds. However, their efficacy and underlying mechanisms in animal models of gastric ulcers is uncertain, necessitating a comprehensive and systematic evidence-based evaluation. Hence, there is a compelling need for a rigorous assessment to address these gaps in knowledge.
- Study Type Included
- Inclusion criteria: Published randomized controlled animal experiments (in vivo studies) with a separate control group. Exclusion criteria: Case reports, clinical trial studies, cross-over studies, studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: There is no restriction on the race, category, weeks of age, and sex of the included animals. Any animal used for gastric ulcer (GU)modeling will be included. Exclusion criteria: Not an animal model of GU.
- Human Disease Modelled
- Gastric ulcer
- Intervention
- Inclusion criteria: Experimental groups received PAE monotherapy Exclusion criteria: Experimental groups are treated with PAE in combination with other drugs.
- Comparator Control
- Inclusion criteria: Control groups were treated with a placebo such as saline solution or no measure of treatment. Exclusion criteria: Control groups were treated with positive drugs and there is no model group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Outcomes related to ulcer healing such as ulcer area, ulcer inhibition rate. Exclusion criteria: no relevant outcomes reported.
- Additional Outcome
- Study Method
- Keyword
- Animals; Bile Acids and Salts; Cardia; Caustics; Defense Mechanisms; Eructation; Financial Stress; Gastric Acid; Gastric Mucosa; Humans; Hydrochloric Acid; Incidence; Peptide Hydrolases; Periplaneta; Prevalence; Pylorus; Stomach Ulcer; Ulcer; kangfuxin
- Contact
- tingting he [email protected]
- Organisational Affiliation
- Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
- Funding Source
- The National Natural Science Foundation of China provided funding for this project. Grant number(s) No.82274247
- Other Selection Criteria
- Inclusion criteria: languages: English and Chinese, all publication dates. Exclusion criteria: publication types: reviews, conference abstracts.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-04
- Registration Date
- 2023-10-17
- Anticipated Start Date
- 2023-10-18
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 美洲大蠊提取物在胃溃疡动物模型中的有效性及其机制：一项系统评价与Meta分析
- Title En
- Effectiveness and mechanism of Periplaneta americana L. extract in animal models of gastric ulcer: A systematic review and meta-analysis
- Bilingual Status
- complete