Meta AnalysisID 7120
膳食椰子油预防和治疗痴呆症效果的系统评价与Meta分析
CRD42023395601
What is the effect of VCO on cognition and quality of life on ILWD in community and in-patient settings when compared to not consuming VCO in any form?
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Record Fields
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- Meta Analysis Id
- 7120
- Evidence Id
- 15678
- Core Evidence Id
- 15678
- Source Meta Analysis Id
- 7107
- Herb2 Meta Analysis Id
- HBMA007107
- Crd Id
- CRD42023395601
- Title
- The effect of dietary coconut oil in prevention and treatment of dementia: a systematic review and meta-analysis
- Review Question
- What is the effect of VCO on cognition and quality of life on ILWD in community and in-patient settings when compared to not consuming VCO in any form?
- Study Type Included
- The review will consider any meta-analyses and randomised controlled trials (RCTs); in the absence of meta-analyses and RCTs, other research designs of a quantitative nature, such as non-randomised controlled trials, before and after studies, cohort studies, case control studies, descriptive studies, case series/reports will be considered for inclusion on effectiveness of VCO in ILWD in hospital and community healthcare settings.
- Condition Being Studied
- Older adults diagnosed with mild to moderate dementia.
- Participant
- The intervention will be oral consumption of VCO/KD/MCT supplementation to induce ketogenesis on cognition, functioning, memory & behaviour performances and QoL in individuals living with MCI/ AD/Dementia in hospital and community in the UK, no gender restrictions and no ethnicity restrictions. The comparison will be a condition when the individual did not consume VCO in any form & the outcome will be to determine how did the oral consumption of VCO affected the cognition, functioning, memory & behaviour performance. The adverse effects of VCO and the barriers to consume VCO. For the purposes of this systematic review, the population, intervention, comparators and outcomes (PICO) framework are as follows. PICO Population - ILWD Intervention - Oral consumption of VCO Comparison - Not consuming VCO in any form Outcome - Effectiveness on cognitive, functioning, memory & behaviour performance Studies in cognitively healthy individuals, individuals diagnosed with diabetes, cancer, HIV infection, chronic kidney disease, liver disease, or any other condition that may affect lipid metabolism, studies which report multiple chronic conditions and those referred to older frail individuals showing signs of disorientation without a specific diagnosis of dementia will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The intervention will be oral consumption of VCO that aims to affect the cognition, functioning, memory and the behaviour performances positively (Henderson et al. 2009).
- Comparator Control
- Interventions will be compared to usual care which consist of not consuming VCO in any form, or having placebo or any other oils (Fish oil, cod liver oil)
- Main Outcome
- The primary outcome is improve cognitive performance, to monitor the changes from baseline in the AD Assessment Scale–Cognitive (ADAS-Cog, MMSE), Category/Letter Fluency, Activities of Daily Living (ADLs), Neuropsychiatric Inventory, if the effects sustain after cessation of VCO administration, changes in Geriatric Depression Scale, changes in Ketone and C-Reactive Protein assays and adverse events related to VCO usage during the treatment periods. The adverse effects for example gastrointestinal system side effects, diarrhoea, nausea, flatulence, stomach discomfort, hyperactivity or derangements in lipid parameters of VCO (Ota et al 2019; Newport 2014; Gandotra et al 2014; Maynard et al, 2013; Henderson et al, 2009, any dropouts and the barriers to consume VCO. Measures of effect Effect sizes expressed as odds ratio (for categorical data) and weighted mean differences (for continuous data), and their 95% confidence intervals will be calculated for analysis.
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Coconut Oil; Cocos; Cognition; Dementia; Dietary Fats, Unsaturated; Humans; Quality of Life
- Contact
- Kirti Paik-Inkar [email protected]
- Organisational Affiliation
- University of West London https://www.uwl.ac.uk/
- Funding Source
- Self funded Grant number(s) State the funder, grant or award number and the date of award Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-24
- Registration Date
- 2023-09-01
- Anticipated Start Date
- 2023-01-01
- Anticipated Completion Date
- 2023-10-31
- Title Cn
- 膳食椰子油预防和治疗痴呆症效果的系统评价与Meta分析
- Title En
- The effect of dietary coconut oil in prevention and treatment of dementia: a systematic review and meta-analysis
- Bilingual Status
- complete