Meta AnalysisID 7093
益母草注射液联合催产素预防剖宫产孕妇产后出血：系统评价与Meta分析方案
CRD42023416135
Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality in cesarean section, and oxytocin is a commonly used drug for preventing PPH, but it also has some side effects and contraindications. Mother
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Record Fields
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- Meta Analysis Id
- 7093
- Evidence Id
- 15651
- Core Evidence Id
- 15651
- Source Meta Analysis Id
- 7072
- Herb2 Meta Analysis Id
- HBMA007072
- Crd Id
- CRD42023416135
- Title
- Motherwort injection combined with oxytocin for preventing postpartum hemorrhage in pregnant women with cesarean section: protocol of a systematic review and meta-analysis
- Review Question
- Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality in cesarean section, and oxytocin is a commonly used drug for preventing PPH, but it also has some side effects and contraindications. Motherwort injection is a traditional Chinese medicine preparation that has uterine contraction effect and may have synergistic effect with oxytocin. This article aims to compare the efficacy and safety of motherwort injection combined with oxytocin versus oxytocin alone for preventing PPH in cesarean section by meta-analysis. This article will provide evidence support for the rational use of motherwort injection in clinical practice. Compared with previous studies, the advantages of this article may include the following: (1) This article will update the latest relevant literature, including randomized controlled trials published in recent years, to improve the timeliness and credibility of meta-analysis; (2) This article will focus on the efficacy and safety of motherwort injection for PPH in the scenario of combined use of oxytocin.
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Postpartum hemorrhage (PPH) is defined as blood loss of more than 500 mL after vaginal delivery or more than 1000 mL after cesarean section, or blood loss exceeding 10% of the pre-delivery blood volume within 24 hours of delivery. PPH is one of the leading causes of maternal mortality, especially in developing countries. The main risk factors for PPH include uterine atony, retained placenta, uterine rupture, coagulation disorders, etc. The prevention and treatment of PPH are important measures to improve the quality of life and reduce the mortality rate of pregnant and postpartum women.
- Participant
- Inclusion criteria: Women who need to cesarean section during the third stage of labor.
- Animal
- Human Disease Modelled
- Intervention
- Motherwort injection combined with oxytocin
- Comparator Control
- Oxytocin alone
- Main Outcome
- 1. Blood loss within 2 hours after delivery (mL). 2. Blood loss within 24 hours after delivery (mL). 3. The occurrence of postpartum hemorrhage. 4. The occurrence of adverse reactions.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Cesarean Section; Contraindications; Female; Humans; Leonurus; Meta-Analysis as Topic; Oxytocin; Postpartum Hemorrhage; Postpartum Period; Pregnancy; Pregnant Women; Randomized Controlled Trials as Topic; Systematic Reviews as Topic
- Contact
- Liu qingsong [email protected]
- Organisational Affiliation
- Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University
- Funding Source
- National Natural Science Foundation of China Grant number(s) State the funder, grant or award number and the date of award NO. 72174132; NO. 82225049; NO. 71974138
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-16
- Registration Date
- 2023-04-27
- Anticipated Start Date
- 2023-03-01
- Anticipated Completion Date
- 2023-07-01
- Title Cn
- 益母草注射液联合催产素预防剖宫产孕妇产后出血：系统评价与Meta分析方案
- Title En
- Motherwort injection combined with oxytocin for preventing postpartum hemorrhage in pregnant women with cesarean section: protocol of a systematic review and meta-analysis
- Bilingual Status
- complete