Meta AnalysisID 7085
石榴对癌症的影响：系统评价与Meta分析
CRD42023446253
Is pomegranate supplementation effective on cancer complications or recovery?
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Record Fields
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- Meta Analysis Id
- 7085
- Evidence Id
- 15643
- Core Evidence Id
- 15643
- Source Meta Analysis Id
- 7064
- Herb2 Meta Analysis Id
- HBMA007064
- Crd Id
- CRD42023446253
- Title
- The effect of pomegranate on cancer: a systematic review and meta-analysis
- Review Question
- Is pomegranate supplementation effective on cancer complications or recovery?
- Study Type Included
- clinical trials
- Condition Being Studied
- Pomegranate is one of the beneficial fruits that has been used by traditional medicine for hundreds of years and was used to treat dyslipidemia, atherosclerosis, high blood pressure, and various types of cancer, diabetes, stomach ulcers, and oral diseases. However, according to meta-analysis studies, contrary to what was thought in the past, pomegranate is not useful for diabetes and has no effect on FBI, FBG, HbA1c factors. Based on the results of pomegranate studies, with its diverse phytochemicals, it can play a role in cancer through several mechanisms, these mechanisms include induction of apoptosis, antioxidant, and anti-inflammatory properties, anti-proliferative ), tumor anti-angiogenesis, inhibition of tumor invasion, reduction of signaling such as NF-κB, PI3K/AKT/mTOR/Wnt, reduction of expression of anti-apoptotic genes such as MMPs, VEGF, c-met, cyclins Cdks, reduction of pro-inflammatory factors be. Clinical studies have been conducted on the effect of pomegranate on head and neck, prostate, breast, and colorectal cancers. But since the results of the studies are contradictory and no systematic study has been done in this field, this study is the first systematic review of the clinical studies conducted to evaluate the effect of pomegranate on cancer patients.
- Participant
- Patients with cancers
- Animal
- Human Disease Modelled
- Intervention
- pomegrenate supplementation
- Comparator Control
- patients with cancers without any supplementation
- Main Outcome
- The effect of pomegranate on PSA, PSADT, Steroid hormones, Anti-oxidant marker such as MDA, GPX and SOD will be assess.
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Dietary Supplements; Flower Essences; Fruit; Humans; Lythraceae; Neoplasms; Pomegranate
- Contact
- Motahareh Hasani [email protected]
- Organisational Affiliation
- school of public health
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-07-18
- Registration Date
- 2023-07-28
- Anticipated Start Date
- 2023-05-01
- Anticipated Completion Date
- 2023-12-01
- Title Cn
- 石榴对癌症的影响：系统评价与Meta分析
- Title En
- The effect of pomegranate on cancer: a systematic review and meta-analysis
- Bilingual Status
- complete