Meta AnalysisID 7081

评估中药泻药在结肠镜检查肠道准备中的作用：一项系统评价和网状Meta分析

CRD42023424167

Evaluating the role of traditional chinese medicine such as senna leaf for bowel preparation in colonoscopy

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Meta Analysis Id: 7081
Evidence Id: 15639
Core Evidence Id: 15639
Source Meta Analysis Id: 7060
Herb2 Meta Analysis Id: HBMA007060
Crd Id: CRD42023424167
Title: Evaluating the Role of Traditional Chinese Herbal Laxatives for Bowel Preparation in Colonoscopy：A Systematic Review and Network Meta-analysis.
Review Question: Evaluating the role of traditional chinese medicine such as senna leaf for bowel preparation in colonoscopy
Study Type Included: We will only include parallel-group randomized trials. We will include studies regardless of their publication status or the country of origin. We will not consider cross-over or cluster-randomized controlled trials, since these are not applicable to the clinical question of interest.
Condition Being Studied: Colorectal cancer（CRC）is one of the common gastrointestinal cancers, its morbidity and mortality rate continue to rise, making it the second highest incidence tumor in China after lung cancer. The occurrence and development of colorectal cancer mostly follow the sequence of "adenoma-cancer". It generally takes 5-10 years to develop from precancerous lesions to cancer, which provides an important time for early diagnosis and clinical intervention. In China, more than 85% of colorectal cancers are found in the advanced stage. Even with comprehensive treatment such as chemotherapy and radiotherapy, the survival rate of patients does not exceed 40%. After treatment of early-stage colorectal cancer, the 5-year survival rate can exceed 95%. Therefore, early diagnosis and treatment of colorectal cancer are crucial to reduce the mortalityrate of colorectal cancer.Early screening methods for colorectal cancer include colonoscopy, FIT, mtsDNA, Septin9, colon CT imaging, capsule colonoscopy. Among them, colonoscopy is the gold standard for colorectal cancer screening. Its CRC detection rate is 100%, and it can reduce the long-term incidence of CRC by 31-71% and the long-term mortality by 26%. It is a diagnostic and therapeutic technique that can detect cancer and precancerous lesions. The review interval can be as long as 10 years.
Participant: Inclusion criteria: Patients aged ≥18 years who require colonoscopy, no matter in outpatient clinics or wards. All patients signed the informed consent form. Exclusion criteria: refusal of colonoscopy, previous partial colectomy, planned polypectomy, incomplete bowel preparation, renal failure, massive ascites, or known colonic obstruction and so on.
Animal
Human Disease Modelled
Intervention: Bowel preparation using Chinese herbal laxatives, such as senna leaf, rhubarb, glauber and so on.
Comparator Control: Bowel preparation using polyethylene glycol or other non-Chinese herbal laxatives, such as dimethyl silicone oil, lactilose, compound sodium picosulfate, olive oil and so on.
Main Outcome: Boston bowel preparation scale(continuous outcome): BBPS, segment scores defined as follows. Score 0: unprepared colon segment, mucosa not seen due to solid stool that cannot be cleared. Score 1: portion of mucosa of colon segment seen, but other areas of the segment not well seen due to staining, residual stool and/or opaque liquid. Score 2: minor amount of residual staining, small fragments of stool and/or opaqueliquid, but mucosa of segment seen well. Score 3: entire mucosa of segment seen well with no residual staining, small fragments of stool and/or opaque liquid. Overall Adenoma detection rate(dichotomous outcome)：defined as the proportion of patients with at least one adenoma, is one of the most important quality indicators in colonoscopy.
Outcome Measure
Additional Outcome: Cecal intubation rate(dichotomous outcome)：defined as insertion beyond the ileocecal valve with visualization of the appendix opening. Overall Adenoma detection rate(dichotomous outcome): defined as the proportion of patients with at least one adenoma, is one of the most important quality indicators in colonoscopy. Cecal intubation time(continuous outcome): defined as time for passage of the colonoscope from the rectum to the cecum. A stopwatch was used to time the procedures. Recent studies have shown that it is also an important quality indicators in colonoscopy.
Study Method: Network meta-analysis, Systematic review
Keyword: Cathartics; Colonoscopy; Humans; Laxatives; Network Meta-Analysis
Contact: Xujin Chen [email protected]
Organisational Affiliation: The Affiliated Wuxi People's Hospital of Nanjing Medical University
Funding Source: Funding scheme for young and middle-aged top talent of Wuxi health commission Grant number(s) State the funder, grant or award number and the date of award BJ2020011
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: China
Review Stage: Review Ongoing
First Submission Date: 2023-05-06
Registration Date: 2023-05-17
Anticipated Start Date: 2023-05-01
Anticipated Completion Date: 2023-10-31
Title Cn: 评估中药泻药在结肠镜检查肠道准备中的作用：一项系统评价和网状Meta分析
Title En: Evaluating the Role of Traditional Chinese Herbal Laxatives for Bowel Preparation in Colonoscopy：A Systematic Review and Network Meta-analysis.
Bilingual Status: complete