Meta AnalysisID 7047
枇杷（Eriobotrya japonica）治疗2型糖尿病的疗效：临床前研究的系统评价和Meta分析
CRD42023435600
Could Eriobotrya japonica administration slow the progression of diabetes in an in vivo rodent model? Context and rationale Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated levels of glu
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Record Fields
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- Meta Analysis Id
- 7047
- Evidence Id
- 15605
- Core Evidence Id
- 15605
- Source Meta Analysis Id
- 7030
- Herb2 Meta Analysis Id
- HBMA007030
- Crd Id
- CRD42023435600
- Title
- The Efficacy of Eriobotrya japonica for the Treatment of Type 2 diabetes mellitus: A Systematic Review and Meta-Analysis of Preclinical Studies
- Review Question
- Could Eriobotrya japonica administration slow the progression of diabetes in an in vivo rodent model? Context and rationale Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated levels of glucose in the blood. Additionally, it results in microvascular and macrovascular problems that are extremely painful for both patients and nursing staff, straining the healthcare system to its breaking point. Despite the increasing awareness of the risk factors for diabetes, the global prevalence and incidence are increasing. Loquat (Eriobotrya japonica) belongs to the Rosaceae family and is a perennial fruit that has been utilized as a well-known and longstanding botanical medicine in China. It has been reported that Eriobotrya japonica are widely used in the treatment of skin diseases, coughs, diabetes and cardiovascular diseases. So far, there has been a dearth of clinical trials assessing the effectiveness of Eriobotrya japonica in treating type 2 diabetes mellitus patients. Therefore, a meticulous review of animal studies could furnish definitive proof for forthcoming clinical trials.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group. Exclusion criteria: Studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Mice and rat experimental models with diabetes mellitus diseases, all species and all sexes. (no restriction applies) Exclusion criteria: Studies in humans, in vitro, ex vivo, study designs
- Human Disease Modelled
- Type 2 diabetes mellitus
- Intervention
- Inclusion criteria: Treatment with Eriobotrya japonica in any dosing, given at any time and frequency of dosing. Exclusion criteria: Trials with unclear timing, frequency, or treatment dosage are not included.
- Comparator Control
- Inclusion criteria: A vehicle/placebo, a conventional therapy, or a health control were all employed in an animal model of DM. Exclusion criteria: Diabetes mellitus animal models that have been given any other medication.
- Main Outcome
- Outcome Measure
- Inclusion criteria: The primary outcomes measures included: Serum glucose level, HOMA-IR levels, insulin levels. The secondary utcomes measures included: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDH-C). Exclusion criteria: no relevant outcomes reported
- Additional Outcome
- Study Method
- Keyword
- Animals; Cardiovascular Diseases; Cough; Diabetes Mellitus, Type 2; Eriobotrya; Fruit; Glucose; Humans; Incidence; Metabolic Diseases; Prevalence; Rodentia; Rosaceae
- Contact
- Chui Hinsan [email protected]
- Organisational Affiliation
- Chengdu university of tcm
- Funding Source
- This work was supported by renal protection based TCM protocol for allergic purpura (Ref 2021YJ0153). Funding is provided by Sichuan Province Science and Technology Support Program.
- Other Selection Criteria
- These databases were searched for relevant studies published during establishment till March, 2023, were eligible for inclusion. Furthermore, a manual search for relevant literature for the study was performed to obtain a more comprehensive list of references.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-14
- Registration Date
- 2023-06-27
- Anticipated Start Date
- 2023-06-15
- Anticipated Completion Date
- 2023-11-01
- Title Cn
- 枇杷（Eriobotrya japonica）治疗2型糖尿病的疗效：临床前研究的系统评价和Meta分析
- Title En
- The Efficacy of Eriobotrya japonica for the Treatment of Type 2 diabetes mellitus: A Systematic Review and Meta-Analysis of Preclinical Studies
- Bilingual Status
- complete