Meta AnalysisID 7024
不同类型坚果对成人肠道微生物组组成及肠道功能比较疗效的网状Meta分析
CRD42023451282
What is the effect of the different types of nuts (almond, hazelnut, macadamia, pistachio, walnut, pecan, pine nut, Brazil nut, cashew, peanut) on gut microbiota composition in adults?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7024
- Evidence Id
- 15582
- Core Evidence Id
- 15582
- Source Meta Analysis Id
- 7008
- Herb2 Meta Analysis Id
- HBMA007008
- Crd Id
- CRD42023451282
- Title
- A network meta-analysis on the comparative efficacy of the different types of nuts on gut microbiome composition and gut function in adults
- Review Question
- What is the effect of the different types of nuts (almond, hazelnut, macadamia, pistachio, walnut, pecan, pine nut, Brazil nut, cashew, peanut) on gut microbiota composition in adults?
- Study Type Included
- Clinical controlled trials with parallel or crossover design that used at least one type of nut as intervention for at least a week. In the case of crossover trials, only those with a washout period will be eligible.
- Condition Being Studied
- We are investigating the effect of the different types of nuts on the composition of gut microbiota, and gut function and symptoms in adults.
- Participant
- Inclusion: adults (≥18 years) Exclusion: trials conducted in population <18 years
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: all intervention trials (with at least 1-week length) that included at least one type of nut (almond, hazelnut, macadamia, pistachio, walnut, pecan, pine nut, Brazil nut, cashew, peanut) in comparison to a control/placebo/non-intervention. Different types of whole nut processing are eligible (e.g. chop, ground, butter, with/without skin). Exclusion: trials that used nuts combined with other interventions that preclude the assessment of the effect of nut consumption alone; trials that did not assess the effects of whole nuts (e.g. oils or extracts)
- Comparator Control
- Controls or placebos without the consumption of nuts; different types of nuts.
- Main Outcome
- Between-group differences in the following markers at the end of the intervention: - global microbiome composition - alpha-diversity of faecal microbiota - beta-diversity of faecal microbiota - Bifidobacterium spp - Lactobacillus spp - Roseburia spp - Akkermansia municiphila - Eubacterium hallii - Eubacterium rectale - Faecalibacterium prausnitzii - Ruminococcus bromii Measures of effect Outcomes related to the gut microbiome as assessed by all relevant measurement methods will be included.
- Outcome Measure
- Additional Outcome
- The following between-group differences at the end of the intervention will be analysed as ‘exploratory outcomes’: - Faecal or plasma short chain fatty acids; - Gastrointestinal symptoms; - Stool frequency and consistency; - Differences in bacterial taxa (not previously specified as secondary outcomes); - Faecal metabolites; - Urine metabolites; - Serum/plasma metabolites.
- Study Method
- Meta-analysis, Network meta-analysis, Systematic review
- Keyword
- Allergens; Anacardium; Arachis; Bertholletia; Carya; Corylus; Fabaceae; Gastrointestinal Microbiome; Humans; Juglans; Macadamia; Nuts; Pistacia; Prunus dulcis
- Contact
- Barbara R Cardoso [email protected]
- Organisational Affiliation
- Monash University https://research.monash.edu/en/persons/barbara-cardoso
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-03
- Registration Date
- 2023-08-14
- Anticipated Start Date
- 2023-08-10
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 不同类型坚果对成人肠道微生物组组成及肠道功能比较疗效的网状Meta分析
- Title En
- A network meta-analysis on the comparative efficacy of the different types of nuts on gut microbiome composition and gut function in adults
- Bilingual Status
- complete