Meta AnalysisID 7022
白果槲寄生治疗犬鳞状细胞癌或基底细胞癌的疗效：系统评价方案
CRD42023418380
To define the investigation questions, it was considered the PICO acronymous, as follow: - Participants – dogs with squamous or basal cell carcinoma (SCC/BCC); - Intervention – adjuvant treatment with Viscum album; - Com
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Record Fields
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- Meta Analysis Id
- 7022
- Evidence Id
- 15580
- Core Evidence Id
- 15580
- Source Meta Analysis Id
- 7006
- Herb2 Meta Analysis Id
- HBMA007006
- Crd Id
- CRD42023418380
- Title
- EFFICACY OF VISCUM ALBUM IN THE TREATMENT OF SQUAMOUS OR BASAL CELL CARCINOMA IN DOGS - PROTOCOL OF A SYSTEMATIC REVIEW
- Review Question
- To define the investigation questions, it was considered the PICO acronymous, as follow: - Participants – dogs with squamous or basal cell carcinoma (SCC/BCC); - Intervention – adjuvant treatment with Viscum album; - Comparator – control group or no treatment, conventional chemotherapy; - Outcome – response rate (complete or partial remission, stable disease or disease in progression), and rate and time of survival. The question will be “the use of Viscum album as adjuvant in the treatment of SCC/BCC in dogs improves the response rate and/or the survival time?" Context and rationale In humans, squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer after basal cell carcinoma. SCC accounts for 20% of cutaneous malignancies and about 75% of all deaths due to skin cancer, excluding melanoma. Its incidence rate is constantly increasing, mainly due to population aging. In pets, Squamous Cell Carcinoma (SCC) is defined as a relatively common malignant neoplasm, accounting for 5% of all skin tumors. It is considered the second most common oral cancer type (31%) in dogs and cats. Cancer chemotherapy in dogs has traditionally involved administration of chemotherapy agents at the maximum tolerated dose. Cytotoxic chemotherapy has an acceptably low risk of serious toxicity, but an obligatory rest period must be included to allow for recovery of drug-sensitive normal cell populations. This rest period can also allow significant recovery of tumor cells. The traditional chemotherapy present side effects that can impair the patients life quality. Among the various properties of the Viscum album plant, the most outstanding are anticancer, cardiotonic, antidiabetic, hepatoprotective, antioxidant, antibacterial, antifungal, and immunomodulatory activities It is expected that Viscum album induces apoptosis and shows immunomodulatory and cytotoxic activity after administration in patients. Extract of Viscum album is one of the most used integrative therapy against cancer in Central Europe. In the world, approximately half of the patients with cancer use complementary therapies, such as Viscum album, so the results obtained with animals may be extrapoled to humans.
- Study Type Included
- Inclusion criteria: controlled studies with a control group Exclusion criteria: studies without a control group, epidemiological studies, case studies, cross-over studies
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: dogs with squamous or basal cell carcinoma in all stages (all sexes, all ages, all breeds). Exclusion criteria: dogs with other carcinoma types, ex vivo, in vitro and in silico models
- Human Disease Modelled
- Carcinoma; complementary medicine; alternative treatment; adjuvant treatment; better response rate
- Intervention
- Inclusion criteria: adjuvant treatament of SCC/BCC in dogs with Viscum album (all timings, frequencies and dosages of treatment are eligible for inclusion) Exclusion criteria: adjuvant treatment of SCC/BCC in dogs with any other alternative substance
- Comparator Control
- Inclusion criteria: control group or animals undergoing no treatment, conventional chemotherapy Exclusion criteria: any other cancer treatment type different from conventional chemotherapy
- Main Outcome
- Outcome Measure
- Inclusion criteria: rate response (complete or partial response, stable disease or disease in progression), rate and time of survival Exclusion criteria: no relevant outcomes reported
- Additional Outcome
- Study Method
- Keyword
- Aging; Animals; Anti-Bacterial Agents; Antifungal Agents; Antioxidants; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cardiotonic Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Humans; Hypoglycemic Agents; Incidence; Maximum Tolerated Dose; Melanoma, Cutaneous Malignant; Pharmaceutical Preparations; Skin Neoplasms; Systematic Reviews as Topic; Viscum album
- Contact
- Maria Cristina de Oliveira [email protected]
- Organisational Affiliation
- Universidade de Rio Verde http://www.unirv.edu.br
- Funding Source
- there are no funding sources
- Other Selection Criteria
- Inclusion criteria: all language, all publication data Exclusion criteria: none
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-04-19
- Registration Date
- 2023-05-17
- Anticipated Start Date
- 2023-08-31
- Anticipated Completion Date
- 2024-03-31
- Title Cn
- 白果槲寄生治疗犬鳞状细胞癌或基底细胞癌的疗效：系统评价方案
- Title En
- EFFICACY OF VISCUM ALBUM IN THE TREATMENT OF SQUAMOUS OR BASAL CELL CARCINOMA IN DOGS - PROTOCOL OF A SYSTEMATIC REVIEW
- Bilingual Status
- complete