Meta AnalysisID 7018
口腔黏膜下纤维性变的药物治疗：系统评价
CRD42023429093
To evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).
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Record Fields
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- Meta Analysis Id
- 7018
- Evidence Id
- 15576
- Core Evidence Id
- 15576
- Source Meta Analysis Id
- 7003
- Herb2 Meta Analysis Id
- HBMA007003
- Crd Id
- CRD42023429093
- Title
- Drug treatment for oral submucous fibrosis: a systematic review
- Review Question
- To evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).
- Study Type Included
- RCT, non-RCT studies were included
- Condition Being Studied
- Oral submucous fibrosis (OSF) is an insidious and chronic oral mucosal disease. It is a potentially malignant disorder of the oral mucosa with a malignant transformation rate between 6% and 9%. The initial manifestations of OSF are inflammation, fibrosis occurring after inflammation, and marble-like lesions in the oral mucosa. The late stage of this disease is characterized by a fibrous band that limits mouth opening, which can further cause problems with oral hygiene, speaking, and chewing. The etiology of OSF has not yet been fully elucidated but may be related to betel nut chewing, capsaicin,autoimmunity, allergies, genetic predisposition, and chronic vitamin and micronutrient deficiencies. The current mainstream view is that betel nut chewing is closely associated with the occurrence of OSF. Excessive use of areca nut, collagen synthesis increases and collagen degradation decreases, increased collagen cross-linking, and insufficient collagen phagocytosis and fibrokine action, this eventually leads to OSF. Moreover, the long-term use of areca nut can induce the production of free radicals and reactive oxygen species, leading to a high rate of oxidation/peroxidation of unsaturated fatty acids, which affects the essential components of cell membranes.
- Participant
- Inclusion Criteria 1)Type of study: RCT, non-RCT studies were included; 2) Subjects: patients diagnosed with OSF according to pathological diagnosis or clinical manifestations, regardless of gender and race; 3) Intervention: the experimental group was treated with drugs; 4)The study was conducted from December 2011 to September 2022; 5) Studies were reported in English only. Exclusion criteria (1) incomplete data (2) full text not available (3) Studies with unclear evaluation criteria; (4) Cannot be obtained Bureau index data, literature with incomplete data and wrong data.
- Animal
- Human Disease Modelled
- Intervention
- Intervention group: lycopene, pentoxifylline, curcumin, aloe vera, Omega3 and other drug treatment group. Control group: other drug group
- Comparator Control
- Placebo.A group of drug which the experimental group did not use or blank control.
- Main Outcome
- mouth opening, burning sensation, check flexible Measures of effect MD
- Outcome Measure
- Additional Outcome
- Tongue Protrusion Measures of effect MD
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Oral Submucous Fibrosis
- Contact
- xueru chen [email protected]
- Organisational Affiliation
- School of Stomatology, Hunan University of Chinese Medicine https://www.csskqyy.com/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-23
- Registration Date
- 2023-06-03
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2023-07-31
- Title Cn
- 口腔黏膜下纤维性变的药物治疗：系统评价
- Title En
- Drug treatment for oral submucous fibrosis: a systematic review
- Bilingual Status
- complete