Meta AnalysisID 7013
阿育吠陀草药/香料与安慰剂/对照相比改善肠易激综合征患者症状严重程度的有效性：系统评价与Meta分析
CRD42023372462
What is the effectiveness of Ayurvedic herbs/spices compared to placebo/control for improving the severity of symptoms in patients with irritable bowel syndrome (IBS)? A systematic review and meta-analysis
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Record Fields
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- Meta Analysis Id
- 7013
- Evidence Id
- 15571
- Core Evidence Id
- 15571
- Source Meta Analysis Id
- 6998
- Herb2 Meta Analysis Id
- HBMA006998
- Crd Id
- CRD42023372462
- Title
- Systematic review and meta-analysis of the effectiveness of Ayurvedic herbs/spices compared to placebo/control for improving the severity of symptoms in patients with irritable bowel syndrome (IBS)
- Review Question
- What is the effectiveness of Ayurvedic herbs/spices compared to placebo/control for improving the severity of symptoms in patients with irritable bowel syndrome (IBS)? A systematic review and meta-analysis
- Study Type Included
- Inclusion: Single/double blind RCTs/ Crossover-RCT if trial involves wash-out period to eliminate carry-over effects/ Cluster-RCT. Articles which are published or unpublished, no restriction on publication period. Exclusion: Systematic review/ Cohort study/Case control study/ Cross-sectional study/ Case studies/ Background information/ Opinion papers/ Case series/reports/ Editorials/ Quasi-RCT/ Crossover-RCT that does not involve wash-out period.
- Condition Being Studied
- Irritable bowel syndrome (IBS). IBS is the condition being studied. IBS is a disorder of the digestive system characterised by symptoms including diarrhoea, constipation, abdominal discomfort and abdominal distention. The pathophysiology of IBS appears to be multifactorial, and factors include genetic, environmental, psychosocial factors or gut oversensitivity. Certain symptoms can also co-occur within all types of IBS, including abdominal discomfort, abdominal distention, mucus in stool and fatigue. It is not uncommon for IBS sufferers to undergo psychological distress where episodes of anxiety, depression, and impaired quality of life may be present. Each case of IBS can be unique for individuals depending on various factors, hence why patients may experience IBS at different intensities with varying symptoms.
- Participant
- Inclusion: Patients with IBS symptoms as defined by the Rome criteria. This includes the Rome II, Rome III and the Rome IV criteria. Patients not restricted by sex/gender/ethnicity/age. Exclusion: Patients with conditions other than IBS such as IBD, bowel/gastric cancer, coeliac disease, hyper/hypothyroidism gastric/duodenal ulcers, severe food intolerances. Pregnant women. Those undergoing simultaneous treatment with herbs/spices. Those using antibiotics. Those participating in another study.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Trials using Ayurvedic herbs/spices including turmeric, ginger, liquorice, aloe vera, neem, black pepper, ashwagandha, haritaki, Indian gooseberry, fennel seeds, chamomile and triphala. Or Studies using more than one herb/spice (turmeric, ginger, liquorice, aloe vera, neem, black pepper, ashwagandha, haritaki, Indian gooseberry, fennel seeds, chamomile and triphala) for intervention can be included. Or Studies with multiple intervention arms (turmeric, ginger, liquorice, aloe vera, neem, black pepper, ashwagandha, haritaki, Indian gooseberry, fennel seeds, chamomile and triphala) will be included as long as one is comparator. Exclusion: Dietary change, Exercise, Yoga, Meditation, Massage therapy
- Comparator Control
- Inclusion: Control (no intervention) Or usual care (exercise/hydration/stress management/healthy diet) Or placebo (placebo drug/psychological drug) Exclusion: No control/usual care/placebo
- Main Outcome
- Inclusion - Severity of symptoms as defined by the Rome diagnostic criteria of IBS. This will be measured using the Irritable Bowel Syndrome Severity Scoring System (IBS-SSS), the Gastrointestinal Symptoms Ratings Scale (GSRS) and the Global Symptom Improvement (GSI). Exclusion - Outcomes not reported in one/both groups. Measures of effect Mean difference if data permits or standardised mean difference.
- Outcome Measure
- Additional Outcome
- Not applicable. Measures of effect Not applicable.
- Study Method
- Systematic review
- Keyword
- Humans; Irritable Bowel Syndrome; Patients; Spices
- Contact
- Krishna Chandegra [email protected]
- Organisational Affiliation
- University of Birmingham https://www.birmingham.ac.uk/index.aspx
- Funding Source
- No funding allocation Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-06
- Registration Date
- 2023-09-07
- Anticipated Start Date
- 2023-07-09
- Anticipated Completion Date
- 2024-09-30
- Title Cn
- 阿育吠陀草药/香料与安慰剂/对照相比改善肠易激综合征患者症状严重程度的有效性：系统评价与Meta分析
- Title En
- Systematic review and meta-analysis of the effectiveness of Ayurvedic herbs/spices compared to placebo/control for improving the severity of symptoms in patients with irritable bowel syndrome (IBS)
- Bilingual Status
- complete