Meta AnalysisID 6976
冬虫夏草治疗慢性阻塞性肺疾病：基于啮齿类动物数据的系统评价与Meta分析
CRD42023428825
Does supplementation of cordyceps or its related artificial substitutes, such as Bailing capsules, have a preventive or improving effect on chronic obstructive pulmonary disease ( COPD ) ? Population (P): animal models o
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- Meta Analysis Id
- 6976
- Evidence Id
- 15534
- Core Evidence Id
- 15534
- Source Meta Analysis Id
- 6957
- Herb2 Meta Analysis Id
- HBMA006957
- Crd Id
- CRD42023428825
- Title
- Cordyceps in the treatment of Chronic obstructive pulmonary disease (COPD) : a systematic review and meta-analysis of rodent data
- Review Question
- Does supplementation of cordyceps or its related artificial substitutes, such as Bailing capsules, have a preventive or improving effect on chronic obstructive pulmonary disease ( COPD ) ? Population (P): animal models of COPD Intervention (I): cordyceps and its substitutes supplemented diet Comparison (C): COPD group Outcomes (O): changes of respiratory function and inflammatory markers Context and rationale Chronic Obstructive Pulmonary Disease (COPD) is a common disease of the respiratory system, characterized by persistent airfow limitation. COPD is caused by the continued chronic infammation when airways are exposed to cigarette smoke, noxious particles, or smoke from biomass fuels. It has been a major cause of chronic morbidity and mortality throughout the world, especially in developing countries. Chronic obstructive pulmonary disease ( COPD ) is a widespread disease that has become the third leading cause of death in humans. In preclinical studies, COPD animal model is an effective way to solve this worldwide problem. Finding effective interventions for the COPD model is of great significance for the treatment of this disease. Cordyceps is a traditional Chinese drug that can improve lung functionality when used to treat COPD patients. By systematically collating published preclinical data, this study aims to systematically evaluate the preclinical efficacy of cordyceps and its substitutes in the treatment of COPD, providing a reference and basis for the development and application of cordyceps related preparations.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group Exclusion criteria: Case studies
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Species: all related species at all available studies, such as Wister rats, SD rats, and Balb / c mice in rodents. Sex: male and female. Disease model: cigarette smoke or cigarette smoke combined with LPS-induced COPD. Exclusion criteria: Species are humans, not animals
- Human Disease Modelled
- Chronic Obstructive Pulmonary Disease (COPD)
- Intervention
- Inclusion criteria: Cordyceps and its substitutes (Jinshuibao capsule, Bailing capsule, Zhiling capsule, and artificial cordyceps mycelium) Exclusion criteria: Interventions are not cordyceps or cordyceps substitutes, such as Cordyceps militaris.
- Comparator Control
- Inclusion criteria: Vehicle-treated control animals Exclusion criteria: No treatment
- Main Outcome
- Outcome Measure
- Inclusion criteria: The major outcomes include spirometric parameters (FEV1% predicted or FEV1/FVC ratio), six-minute walk distance (6MWD), St. George's Respiratory Questionnaire (SGRQ) total score, and frequency of exacerbation. The minor outcomes include immunologic function, effective rate, and blood gas measurement. Exclusion criteria: Mortality
- Additional Outcome
- Study Method
- Keyword
- Animals; Biomass; Cigarette Smoking; Cordyceps; Developing Countries; Dietary Supplements; Humans; Morbidity; Pulmonary Disease, Chronic Obstructive; Rodentia; bailing capsules
- Contact
- Yong Li [email protected]
- Organisational Affiliation
- Chengdu university of traditional chinese medicine https://www.cdutcm.edu.cn/
- Funding Source
- National Natural Science Foundation of China Grant number(s) 81872959
- Other Selection Criteria
- Reviews, case reports, conferences, nonRCTs, and studies involving animals will be excluded.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-23
- Registration Date
- 2023-09-06
- Anticipated Start Date
- 2023-05-23
- Anticipated Completion Date
- 2023-12-24
- Title Cn
- 冬虫夏草治疗慢性阻塞性肺疾病：基于啮齿类动物数据的系统评价与Meta分析
- Title En
- Cordyceps in the treatment of Chronic obstructive pulmonary disease (COPD) : a systematic review and meta-analysis of rodent data
- Bilingual Status
- complete