Meta AnalysisID 6975
山竹果提取物对糖尿病患者血糖及其他指标的影响：系统评价与Meta分析
CRD42023426254
Does Garcinia mangostana extract reduce the blood glucose level in diabetic mice and rat models? Context and rationale Diabetes mellitus (DM) is a metabolic syndrome and endocrinopathy. The number of diabetic mellitus pa
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Record Fields
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- Meta Analysis Id
- 6975
- Evidence Id
- 15533
- Core Evidence Id
- 15533
- Source Meta Analysis Id
- 6956
- Herb2 Meta Analysis Id
- HBMA006956
- Crd Id
- CRD42023426254
- Title
- Effect of Garcinia mangostana extract on blood glucoses and other parameters in diabetes mellitus: a systematic review and meta-analysis
- Review Question
- Does Garcinia mangostana extract reduce the blood glucose level in diabetic mice and rat models? Context and rationale Diabetes mellitus (DM) is a metabolic syndrome and endocrinopathy. The number of diabetic mellitus patients has rapidly increased in recent years. DM is a chronic disease characterized by high blood glucose levels. Hyperglycemia or high blood sugar is an effect of uncontrolled diabetes mellitus that leads to damage in many organs (retinopathy, neuropathy, neuropathy, blood vessels, cardiac problems) and activates oxidative stress in cell membranes by producing reactive oxygen species. Therefore, plant preparations contain antioxidants and hypoglycemic properties which would be as an ingredient in diabetic treatment. Garcinia mangostana, known as mangosteen has many biological activities. Previous evidence has suggested that the anti-diabetic effect of Garcinica mangostana extract in in vitro models. However, a limited of number of clinical studies have been conducted on individual with diabetes mellitus. A single dose (2, 175 mg/day) of Garcinia mangostana extract for 90 days in patient with type 2 DM did not reduce fasting blood glucose levels compared with control group. In high risk cardiovascular patients, there was no difference in fasting blood glucose for a group given 2, 520 mg/day Garcinia mangostana Linn extracts. Reduction in blood glucose was found in obese human subjects supplemented with Merastin (Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds). These inconsistencies are due to the limited number of subjects and the differences in the study design among clinical trials. Therefore, data analysis from previously published researches will be conducted to evaluate the effect of Garcinia mangostana extract on diabetic mice and rat models in this study.
- Study Type Included
- Inclusion criteria: Animal studies (all rodent species): Individual experimental studies with control groups Exclusion criteria: Studies without a separate control group
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All rodent species, animals with induced diabetes mellitus, all sex, all ages Exclusion criteria: (1) In vitro study; (2) animals that are not rodents; (3) animals without diabetes induction
- Human Disease Modelled
- Diabetes mellitus (DM)
- Intervention
- Inclusion criteria: (1) Animal studies which evaluate the different ways of using Garcinia mangostana in its different parts will be included; (2) different types of extraction; (3) different routes of administration. Exclusion criteria: (1) Isolated compounds from Garcinia mangostana; (2) modified Garcinia mangostana compounds or combination treatment with other herbs or chemicals
- Comparator Control
- Inclusion criteria: Animal models of diabetes treated with vehicle/placebo or standard treatment and healthy animal control. Exclusion criteria: None of control/comparators
- Main Outcome
- Outcome Measure
- Inclusion criteria: Mean blood glucose level of the diabetic and treated groups. Exclusion criteria: No relevant outcome reported (blood glucose level)
- Additional Outcome
- Study Method
- Keyword
- Animals; Antioxidants; Asteraceae; Blood Glucose; Cell Membrane; Chronic Disease; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endocrine System Diseases; Fasting; Fruit; Garcinia mangostana; Humans; Hyperglycemia; Hypoglycemic Agents; Inflorescence; Metabolic Syndrome; Mice; Obesity; Oxidative Stress; Rats; Reactive Oxygen Species; Research Subjects; Retinal Diseases
- Contact
- Moragot Chatatikun [email protected]
- Organisational Affiliation
- Walailak University
- Funding Source
- The authors would like to acknowledge the Center of Excellence Research for Melioidosis and Microorganisms, Walailak University for supporting this review.
- Other Selection Criteria
- Inclusion criteria: English language, all publication dates. Exclusion criteria: Other languages
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Thailand
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-13
- Registration Date
- 2023-06-06
- Anticipated Start Date
- 2023-05-13
- Anticipated Completion Date
- 2024-07-31
- Title Cn
- 山竹果提取物对糖尿病患者血糖及其他指标的影响：系统评价与Meta分析
- Title En
- Effect of Garcinia mangostana extract on blood glucoses and other parameters in diabetes mellitus: a systematic review and meta-analysis
- Bilingual Status
- complete