Meta AnalysisID 6955
百香果产品对糖尿病影响的临床前体内模型系统评价
CRD42023472406
What is the effect of Passiflora edulis products on diabetes mellitus in pre-clinical in vivo models? Context and rationale Passiflora edulis is a species native of Brazil, but also distributed in tropical and warm regio
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Record Fields
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- Meta Analysis Id
- 6955
- Evidence Id
- 15513
- Core Evidence Id
- 15513
- Source Meta Analysis Id
- 6989
- Herb2 Meta Analysis Id
- HBMA006989
- Crd Id
- CRD42023472406
- Title
- Influence of Passiflora edulis products on diabetes mellitus in pre-clinical in vivo models: a systematic review.
- Review Question
- What is the effect of Passiflora edulis products on diabetes mellitus in pre-clinical in vivo models? Context and rationale Passiflora edulis is a species native of Brazil, but also distributed in tropical and warm regions of the globe. Brazil is currently the world's largest producer of its fruit, due to the industrial production of the juice. This species, rich in phenolic compounds, has documented several pharmacological activities, such as anxiolytic, anti-inflammatory, antioxidant, antilipidemic and antiglycemic. The popular herbal use of its parts, such as leaves, bark and seeds, is widespread, mainly as an adjuvant in the control of diabetes mellitus. The species appears in official documents in Brazil, such as the National Phytotherapy Form of the Brazilian Pharmacopeia (NPFBP) and the List of Medicinal Plants of Interest to the Unified Health System (RENISUS), however, there is still no product registered with the National Health Surveillance Agency (ANVISA). In this context, seeking to understand the role of the species on diabetes mellitus (which is a chronic condition of multifactorial etiology that occurs when the pancreas no longer produces enough insulin or the body develops insulin resistance) and aiming for a potential sustainable use of the leaves and bark, which are currently considered a byproduct, it is justified to conduct a systematic review on the influence of Passiflora edulis on Diabetes Mellitus in a preclinical in vivo model.
- Study Type Included
- Inclusion criteria: Pre-clinical in vivo studies Exclusion criteria: 1) Clinical studies 2) Pre-clinical in vitro studies
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: 1) All animals models with Diabetes mellitus disease; 2) All species; 3) both sexes Exclusion criteria: 1) In vitro studies
- Human Disease Modelled
- Diabetes Mellittus
- Intervention
- Inclusion criteria: 1) Treatment with any parts of Passiflora edulis; 2) Timing: Not limited; 3) Frequency: Not limited; 4) Dosage: Not limited Exclusion criteria: No exclusion criterias
- Comparator Control
- Inclusion criteria: 1) No treatment; 2) Treated with salina; 3) Treated with vehicle; 4) Treated with antihiperglicemic drugs Exclusion criteria: No exclusion criterias
- Main Outcome
- Outcome Measure
- Inclusion criteria: Blood glucose, glicated hemoglobin, glicogen, lipidemic profile, oxidative markers, inflammatory markers. Exclusion criteria: None.
- Additional Outcome
- Study Method
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Luiz Ricardo Teixeira de Farias [email protected]
- Organisational Affiliation
- Federal University of Rio Grande do Norte
- Funding Source
- No funding
- Other Selection Criteria
- Inclusion criteria: 1) All languages; 2) All publication dates; Exclusion criteria: 1) Reviews; 2) Conference abstracts;
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-31
- Registration Date
- 2023-12-06
- Anticipated Start Date
- 2022-09-26
- Anticipated Completion Date
- 2024-08-19
- Title Cn
- 百香果产品对糖尿病影响的临床前体内模型系统评价
- Title En
- Influence of Passiflora edulis products on diabetes mellitus in pre-clinical in vivo models: a systematic review.
- Bilingual Status
- complete