Meta AnalysisID 6927
绒毛钩藤提取物减轻炎症：一项系统评价
CRD42023450869
Which inflammatory diseases can be treated by Uncaria tomentosa extracts and which inflammatory mediators are involved? Context and rationale The review will provide relevant information about the functioning and mechani
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6927
- Evidence Id
- 15485
- Core Evidence Id
- 15485
- Source Meta Analysis Id
- 6912
- Herb2 Meta Analysis Id
- HBMA006912
- Crd Id
- CRD42023450869
- Title
- Uncaria tomentosa extract decreases inflammation: a systematic review
- Review Question
- Which inflammatory diseases can be treated by Uncaria tomentosa extracts and which inflammatory mediators are involved? Context and rationale The review will provide relevant information about the functioning and mechanism of action of Uncaria tomentosa extract in inflammatory models, providing conditions for research on herbal medicines to be used in pathological conditions. Inflammation is a critical, physiologic response to potential danger signals and damages in organs of the body. However, in inflammatory diseases, an exaggerated immune response further damages organs and tissues. These painful and, in some cases, progressively debilitating conditions can take a toll on people’s quality of life and create both societal and economic burdens.
- Study Type Included
- Inclusion criteria: Controlled studies with separate treatment groups and crossover studies. Exclusion criteria: Non-controlled studies, review articles, meta-analyses, abstracts, conference papers, editorials/letters, and case reports.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: We will include in vitro and in vivo studies comparing Uncaria tomentosa extracts with a control group in inflammatory models that report inflammatory outcomes. Exclusion criteria: In silico, in vitro, ex vivo, or human studies will be excluded.
- Human Disease Modelled
- Inflammatory diseases, such as: osteoarthritis, rheumatoid arthritis, diabetes mellitus, Alzheimer’s disease, Parkinson’s disease, sepsis, non-alcoholic fatty liver disease, asthma etc.
- Intervention
- Inclusion criteria: Uncaria tomentosa extracts, any kind of extract, any route, any dose, and any duration. Exclusion criteria: We will exclude studies that analyze isolated molecules or mixtures of plants.
- Comparator Control
- Inclusion criteria: Control: no treatment, placebo, or standard treatment Exclusion criteria: none
- Main Outcome
- Outcome Measure
- Inclusion criteria: We will include studies that provide rates of change for inflammatory mediators and markers such as cytokines and cell counts. Exclusion criteria: None
- Additional Outcome
- Study Method
- Keyword
- Animals; Cat's Claw; Financial Stress; Humans; Inflammation; Inflammation Mediators; Plant Extracts; Plants, Medicinal; Quality of Life
- Contact
- Mr. Gustavo Marin Arado [email protected]
- Organisational Affiliation
- University of Ribeirão Preto
- Funding Source
- Other Selection Criteria
- Conference abstracts, reviews on the subject and studies published in languages other than English will not be included.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-01
- Registration Date
- 2023-09-26
- Anticipated Start Date
- 2023-07-01
- Anticipated Completion Date
- 2023-10-16
- Title Cn
- 绒毛钩藤提取物减轻炎症：一项系统评价
- Title En
- Uncaria tomentosa extract decreases inflammation: a systematic review
- Bilingual Status
- complete