Meta AnalysisID 6925

针刺与假针刺治疗成人慢性神经病理性疼痛的镇痛疗效和不良事件的系统评价和Meta分析

CRD42023466382

Is acupuncture safe and effective in the treatment of chronic neuropathic pain in adults?

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Meta Analysis Id: 6925
Evidence Id: 15483
Core Evidence Id: 15483
Source Meta Analysis Id: 6910
Herb2 Meta Analysis Id: HBMA006910
Crd Id: CRD42023466382
Title: Systematic review and meta-analysis of the analgesic efficacy and adverse events of acupuncture treatments compared with sham acupuncture for chronic neuropathic pain in adults
Review Question: Is acupuncture safe and effective in the treatment of chronic neuropathic pain in adults?
Study Type Included: We included relevant randomised controlled trials (RCTs) with a treatment duration of eight weeks or longer. We only included studies published in a journal, with the exception of online summaries of otherwise unpublished clinical trials and abstracts with sufficient data for analysis. We excluded studies that were non‐randomised or quasi‐randomised (e.g. allocation by odd or even date of birth), studies of experimental pain, case reports, and clinical observations.
Condition Being Studied: Neuropathic pain is a complex, chronic pain caused by damaged nerves. It is different from pain messages that are carried along healthy nerves from damaged tissue (for example, a fall or cut, or arthritic knee). Approximately 7% to 10% of the general population have neuropathic pain. Acupuncture is a traditional Chinese medicine (TCM) technique of treating disease by inserting needles into the skin, or the tissues below.
Participant: Adults aged 18 years and above with one or more chronic neuropathic pain conditions.
Animal
Human Disease Modelled
Intervention: Acupuncture either given alone or in combination with other therapies, with acupuncture therapy defined as needle insertion and stimulation of somatic tissues for therapeutic purposes. When acupuncture is given in combination with other therapies, the therapy given to the acupuncture group has to also be given to the control group. We included any stimulation based on needle insertion, for example, electrical stimulation (EA) and warm needling (involving the burning of mugwort on an acupuncture needle inserted in the skin or tissues below to heat the needle). We excluded other methods of stimulating acupuncture points without needle insertion (e.g. direct moxibustion, indirect moxibustion, heat‐sensitive moxibustion, moxa burner moxibustion, crude drug moxibustion, or natural moxibustion). Therefore, we included moxibustion with needle insertion but excluded any other types of moxibustion alone.
Comparator Control: acupuncture versus sham acupuncture; acupuncture versus treatment as usual; acupuncture versus other active therapies (anything that is a planned comparison, e.g. exercise or drug therapy). acupuncture combined with other active therapy versus other active therapy We excluded studies that compared different forms of acupuncture. We also excluded studies with acupuncture assigned to each investigated group (e.g. acupuncture alone versus acupuncture plus adjuvant treatment).
Main Outcome: (1) Participant‐reported pain intensity at the end of treatment measured using a validated visual analogue scale (VAS) or categorical pain scale. We are particularly interested in the number of people who achieve 'no worse than mild pain' (Moore 2013a). We consider 3 out of 10 on a numerical rating scale, or 30/100 mm on a VAS, as 'no worse than mild pain' (Wiffen 2013). (2) Participant‐reported pain relief at the end of treatment measured using a validated VAS or categorical pain scale. Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) defines at least 30% pain relief over baseline as moderate pain relief, and at least 50% pain relief over baseline as substantial pain relief in chronic pain (Dworkin 2008).
Outcome Measure
Additional Outcome: Any pain‐related outcome indicating some improvement Withdrawals due to lack of efficacy, adverse events, and for any cause Participants experiencing any adverse event Participants experiencing any serious adverse event. Serious adverse events typically include any untoward medical occurrence or effect that at any dose results in death, is life‐threatening, requires hospitalisation or prolongation of existing hospitalisation, results in persistent or significant disability or incapacity, is a congenital anomaly or birth defect, is an 'important medical event' that may jeopardise the person, or may require an intervention to prevent one of the above characteristics or consequences. Specific adverse events, particularly somnolence and dizziness Quality of life
Study Method: Meta-analysis, Systematic review
Keyword: MeSH headings have not been applied to this record
Contact: gu yiming [email protected]
Organisational Affiliation: Shanghai University of Traditional Chinese Medicine
Funding Source: The National Natural Science Foundation of China (NSFC, Grant Nos. 81874506), China Grant number(s) State the funder, grant or award number and the date of award Grant Nos. 81874506
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: China
Review Stage: Review Ongoing
First Submission Date: 2023-09-26
Registration Date: 2023-10-07
Anticipated Start Date: 2023-09-23
Anticipated Completion Date: 2023-12-31
Title Cn: 针刺与假针刺治疗成人慢性神经病理性疼痛的镇痛疗效和不良事件的系统评价和Meta分析
Title En: Systematic review and meta-analysis of the analgesic efficacy and adverse events of acupuncture treatments compared with sham acupuncture for chronic neuropathic pain in adults
Bilingual Status: complete