Meta AnalysisID 6915
十字花科蔬菜对癌症保护作用的系统评价
CRD42023443324
What is the relationship between cruciferous vegetables and risk for certain types of cancer? What specific types of cancer risk are protected by consuming cruciferous vegetables? What, if any, cruciferous vegetables are
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6915
- Evidence Id
- 15473
- Core Evidence Id
- 15473
- Source Meta Analysis Id
- 6901
- Herb2 Meta Analysis Id
- HBMA006901
- Crd Id
- CRD42023443324
- Title
- A systematic review to examine protective effects of cruciferous vegetables on cancers
- Review Question
- What is the relationship between cruciferous vegetables and risk for certain types of cancer? What specific types of cancer risk are protected by consuming cruciferous vegetables? What, if any, cruciferous vegetables are protective against certain types of cancers? What specific populations, if any, based on genotypes, benefit from consuming cruciferous vegetables?
- Study Type Included
- Randomized controlled trials, non-randomized controlled trials (pre-post studies, quasi-experimental), prospective cohort studies, retrospective cohort studies, and nested case control studies will be included. Cross-sectional, narrative reviews, systematic reviews, and meta-analyses will be excluded. Studies conducted in countries ranked as high or higher on the Human Development Index will be included.
- Condition Being Studied
- Incidence of primary or first cancers. Cancers of interest include all cancers. Biomarkers that are strongly associated with cancer risk, including : Alpha-fetoprotein (AFP), B-cell immunoglobulin gene rearrangement, BCL2 gene rearrangement, Beta-human chorionic gonadotropin (Beta-hCG), BCR-ABL fusion gene (Philadelphia chromosome), C-kit/CD117, CA-125, CA 27.29, Calcitonin, CD19, CD22, CD25, Chromogranin A (CgA), Cyclin D1 (CCND1) gene rearrangement or expression, Gastrin, 5-hydroxyindoleacetic acid (5-HIAA), Immunoglobulins, IRF4 gene rearrangement, JAK2 gene mutation, Microsatellite instability (MSI) and/or mismatch repair deficient (dMMR), MYC gene expression, MYD88 gene mutation, Myeloperoxidase (MPO), Neuron-specific enolase (NSE), Nuclear matrix protein 22, PML/RARα fusion gene, Prostatic Acid Phosphatase (PAP), Prostate-specific antigen (PSA), T-cell receptor gene rearrangement, Terminal transferase (TdT), Urine catecholamines: VMA and HVA, Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1), FoundationOne CDx (F1CDx) genomic test, Guardant360 CDx genomic test, 17-Gene signature (Oncotype DX GPS test), will also be considered.
- Participant
- Generally healthy human participants, or those at risk for chronic disease, or those with obesity but without cancer at baseline, aged ≥18 years old will be included. Pregnant or lactating women and individuals <18 years old will be excluded. Studies that exclusively enroll participants diagnosed with a disease or hospitalized for an illness, injury, or surgery (including bariatric surgery) will be excluded because metabolism can be altered in diseased states and changes in nutrition often becomes part of a medical treatment regimen in these cases.
- Animal
- Human Disease Modelled
- Intervention
- Consumption of whole food cruciferous vegetables, including Armoracia rusticana, Barbarea vulgaris, Brassica campestris, Brassica juncea, Brassica napus, Brassica oleracea, Raphanus sativus, Horseradish, Winter cress, watercress, Turnip, Mustard green, Rutabaga, Kale, collard green, Cauliflower, Cabbage, Brussels sprout, Kohlrabi, Broccoli, Broccoli microgreen, Broccoli sprout, Radish, red radish, white radish, black radish, arugula, rocket-salad, rocketsalad, garden rocket, yellowrocket, Eruca vesicaria, bok choy, pak choi, wasabi, rapeseed, rutabaga, field mustard, Chinese mustard, brown mustard, black mustard, brown mustard, red mustard, garden radish, cultivated radish, Raphanus raphanistrum, Nasturtium officinale, Lepidium meyenii, maca root, maca, Caulanthus, Brassica ruvo, broccoli rabe, rapini, Brassica tournefortii, kohlrabi, mizuna, choy sum, swede, gai lan, kai lan, gai laan, Komatsuna, Japanese mustard spinach, Brassica carinata, Abyssinian mustard, Ethiopian mustard, Ethiopian rape, Brassica carinata A. Braun, B. carinata, seakale, B. campestris, juncea var. rugosa, B. juncea, B. napus, B. oleracea, B. ruvo, B. nigra, B. rapa, B. tournefortii, A. rusticana, B. vulgaris, R. sativus, R. raphanistrum, N. officinale, Nasturtium floridanum, N. floridanum, Nasturtium microphyllum, N. microphyllum, Nasturtium gambelii, N. gambelii, E. vesicaria. Studies using non-whole food cruciferous vegetables, such as freeze-dried powders or dietary supplements, will be excluded.
- Comparator Control
- Lower or no consumption of cruciferous vegetables, as named above.
- Main Outcome
- Incidence of primary or first cancers. Cancers of interest include all cancers. Biomarkers that are strongly associated with cancer risk, including : Alpha-fetoprotein (AFP), B-cell immunoglobulin gene rearrangement, BCL2 gene rearrangement, Beta-human chorionic gonadotropin (Beta-hCG), BCR-ABL fusion gene (Philadelphia chromosome), C-kit/CD117, CA-125, CA 27.29, Calcitonin, CD19, CD22, CD25, Chromogranin A (CgA), Cyclin D1 (CCND1) gene rearrangement or expression, Gastrin, 5-hydroxyindoleacetic acid (5-HIAA), Immunoglobulins, IRF4 gene rearrangement, JAK2 gene mutation, Microsatellite instability (MSI) and/or mismatch repair deficient (dMMR), MYC gene expression, MYD88 gene mutation, Myeloperoxidase (MPO), Neuron-specific enolase (NSE), Nuclear matrix protein 22, PML/RARα fusion gene, Prostatic Acid Phosphatase (PAP), Prostate-specific antigen (PSA), T-cell receptor gene rearrangement, Terminal transferase (TdT), Urine catecholamines: VMA and HVA, Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1), FoundationOne CDx (F1CDx) genomic test, Guardant360 CDx genomic test, 17-Gene signature (Oncotype DX GPS test), will also be considered. Measures of effect Relative risks, odd ratios, or risk differences between groups, intake percentiles, or intake amounts.
- Outcome Measure
- Additional Outcome
- Study Method
- Epidemiologic, Intervention, Meta-analysis, Prevention, Systematic review
- Keyword
- Brassicaceae; Genotype; Humans; Neoplasms; Risk; Vegetables
- Contact
- Thomas Wang, Lauren O'Conner [email protected], [email protected]
- Organisational Affiliation
- United States Department of Agriculture, Agricultural Research Service https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/diet-genomics-and-immunology-laboratory/
- Funding Source
- United States Department of Agriculture appropriated fund Grant number(s) State the funder, grant or award number and the date of award Project # 8040-51530-057-000D
- Other Selection Criteria
- Final Publication
- Same Topic Review
- ot Applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-11
- Registration Date
- 2023-08-22
- Anticipated Start Date
- 2023-05-10
- Anticipated Completion Date
- 2025-05-10
- Title Cn
- 十字花科蔬菜对癌症保护作用的系统评价
- Title En
- A systematic review to examine protective effects of cruciferous vegetables on cancers
- Bilingual Status
- complete