Meta AnalysisID 6875
银杏叶提取物联合多奈哌齐对血管性痴呆患者的影响：一项系统评价和Meta分析方案
CRD42023474678
P：Vascular Dementia；I：Ginkgo biloba+donepezil；C：donepezil；O: MMSE/ADL/Barthel/ inflammatory factors and markers of oxidative stress.；S：RCT. Question:This study aims to investigate the efficacy and safety of combined Gink
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6875
- Evidence Id
- 15433
- Core Evidence Id
- 15433
- Source Meta Analysis Id
- 6861
- Herb2 Meta Analysis Id
- HBMA006861
- Crd Id
- CRD42023474678
- Title
- The effect of Ginkgo biloba extract combined with donepezil on patients with vascular dementia:A protocol for systematic review and meta-analysis
- Review Question
- P：Vascular Dementia；I：Ginkgo biloba+donepezil；C：donepezil；O: MMSE/ADL/Barthel/ inflammatory factors and markers of oxidative stress.；S：RCT. Question:This study aims to investigate the efficacy and safety of combined Ginkgo biloba leaf extractpezil in patients with vascular dementia.
- Study Type Included
- Randomized controlled trials.
- Condition Being Studied
- Vascular dementia is a vascular cognitive impairment, making it the second most common type of dementia after Alzheimer's disease. There are currently no uniform standards for dementia treatment. Common treatments include cholinesterase inhibitors (such as Donepezil, galantamine, and NMDA receptor antagonists such as Memantine), which have been shown to improve cognitive function and score higher on behavioral scales in patients to varying degrees. However, these drugs can produce a variety of adverse reactions, such as digestive tract reactions, joint pain, dizziness, headache, constipation and so on. Since the 1980s, ginkgo biloba extract has been reported as a natural medicine with beneficial effects in many diseases. Although both ginkgo biloba formulations and Donepezil can treat vascular dementia, no meta-analysis studies have explored the efficacy and safety of the combination of ginkgo biloba formulations and Donepezil alone. Therefore, we conducted a meta-analysis of existing trials on the efficacy and safety of ginkgo biloba combined with Donepezil hydrochloride versus Donepezil in the treatment of vascular dementia.
- Participant
- Adult with vascular dementia
- Animal
- Human Disease Modelled
- Intervention
- Ginkgo biloba extract combined with Donepezil
- Comparator Control
- Donepezil
- Main Outcome
- Cognitive function, inflammatory factors and markers of oxidative stress. Measures of effect Which was measured by weighted mean difference (WMD), relative risk (RR) or odds ratio (OR) and 95%CI.
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Liangyi Xiao，Dahua Wu [email protected]
- Organisational Affiliation
- Hunan University of Chinese Medicine，Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine https://www.hnucm.edu.cn/，http://www.zyyfy.com/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-20
- Registration Date
- 2023-10-31
- Anticipated Start Date
- 2023-09-07
- Anticipated Completion Date
- 2023-12-01
- Title Cn
- 银杏叶提取物联合多奈哌齐对血管性痴呆患者的影响：一项系统评价和Meta分析方案
- Title En
- The effect of Ginkgo biloba extract combined with donepezil on patients with vascular dementia:A protocol for systematic review and meta-analysis
- Bilingual Status
- complete