Meta AnalysisID 6863
茴芹对缓解消化不良症状的效果：一项系统评价
CRD42023436969
What is the effect of Pimpinella anisum on relieving symptoms of dyspepsia in adults compared to placebo or standard treatment?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6863
- Evidence Id
- 15421
- Core Evidence Id
- 15421
- Source Meta Analysis Id
- 6850
- Herb2 Meta Analysis Id
- HBMA006850
- Crd Id
- CRD42023436969
- Title
- The Effect of Pimpinella anisum on Relieving Symptoms of Dyspepsia: A Systematic Review
- Review Question
- What is the effect of Pimpinella anisum on relieving symptoms of dyspepsia in adults compared to placebo or standard treatment?
- Study Type Included
- Inclusion Criteria: - Randomized controlled trials (RCTs) evaluating the use of Pimpinella anisum (anise) for relieving symptoms of dyspepsia. - Controlled clinical trials (CCTs) comparing Pimpinella anisum interventions with control groups for dyspepsia symptom relief. - Prospective cohort studies assessing the effectiveness of Pimpinella anisum in managing dyspepsia symptoms. - Case-control studies investigating the association between Pimpinella anisum use and dyspepsia symptom relief. - Systematic reviews and meta-analyses focusing on Pimpinella anisum interventions for dyspepsia symptom relief. - Human clinical studies with sufficient data and outcomes relevant to dyspepsia symptom relief by Pimpinella anisum. - Case reports, case series and editorials. Exclusion Criteria: - Animal studies or preclinical research without human subjects. - Review articles, systematic reviews, and meta-analyses without original data. - Studies with insufficient data or outcomes not relevant to dyspepsia symptom relief. - Studies published in languages other than English or with limited accessibility to the full-text article.
- Condition Being Studied
- The systematic review aims to investigate the effect of Pimpinella anisum on relieving symptoms of dyspepsia. Dyspepsia, as defined by the Rome IV criteria, encompasses a combination of symptoms including postprandial fullness, early satiety, epigastric pain, and epigastric burning, occurring with a frequency of at least three days per week over the course of three months or more, with an onset of at least six months prior. Dyspepsia can manifest as functional dyspepsia, where no organic or structural cause for the symptoms can be identified, or ulcer dyspepsia, commonly caused by H. pylori infection. Gastroesophageal reflux disease (GERD), characterized by symptoms like heartburn, acid reflux, and upper gastrointestinal symptoms, can also contribute to dyspeptic symptoms. The systematic review aims to evaluate the effect of Pimpinella anisum, a medicinal plant commonly known as anise or star anise on relieving symptoms of dyspepsia. By conducting a comprehensive review of relevant studies, the review seeks to provide evidence-based insights into the potential therapeutic benefits of Pimpinella anisum in managing dyspepsia, thereby contributing to the understanding and treatment of this prevalent gastrointestinal condition.
- Participant
- Inclusion Criteria: - Study participants with a confirmed diagnosis of dyspepsia based on recognized medical criteria such as the Rome IV criteria or other clinically accepted diagnostic methods. - Study participants of any age, gender, race, or ethnicity. - Studies including participants with both functional dyspepsia and ulcer dyspepsia will be considered. - Studies conducted in both outpatient and inpatient settings will be included. - Studies involving participants with dyspeptic symptoms related to various etiologies, including but not limited to gastritis, gastric ulcer, peptic ulcer, and Helicobacter pylori infection, will be included. - Studies that involve participants with a range of dyspeptic symptom severity will be included. Exclusion Criteria: - Studies with participants who do not have a confirmed medical diagnosis of any of the conditions being studied. - Studies involving individuals with significant comorbidities (e.g., liver disease, renal disease). - Studies with participants who have undergone gastrointestinal surgery or have any anatomical abnormalities.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion Criteria: - Studies evaluating the use of Pimpinella anisum (anise) as an intervention for dyspeptic symptoms. - Studies examining the administration of Pimpinella anisum in any form, including but not limited to oral ingestion, herbal preparations, extracts, or essential oils. - Studies investigating Pimpinella anisum as a monotherapy or in combination with other interventions or treatments. - Studies comparing the use of Pimpinella anisum against placebo, standard care, or other active interventions. - Studies conducted in any healthcare setting, including hospitals, clinics, or community-based settings. - Studies with various durations of Pimpinella anisum administration, including short-term and long-term interventions. - Studies reporting outcomes related to the relief of dyspepsia symptoms, such as improvement in postprandial distress, reduction in epigastric pain, alleviation of gastric upset, or improvement in overall dyspeptic symptomatology. Exclusion Criteria: - Studies examining interventions or exposures other than Pimpinella anisum for the management of dyspepsia. - Studies investigating the use of Pimpinella anisum for purposes unrelated to dyspepsia symptom relief. - Studies lacking a control group or comparator for evaluating the effectiveness of Pimpinella anisum. - Studies without reported outcomes related to dyspepsia symptom relief or lacking relevant clinical endpoints.
- Comparator Control
- Inclusion Criteria: - Studies comparing the use of Pimpinella anisum (anise) against placebo, sham intervention, or non-exposed control groups. - Studies comparing Pimpinella anisum interventions against standard care or conventional treatments for dyspepsia. - Studies investigating the effectiveness of Pimpinella anisum in comparison to other active interventions or medically recognized alternative treatments for dyspepsia. - Studies with a clear description of the comparator or control group used. Exclusion Criteria: - Studies without a comparator or control group for evaluating the effectiveness of Pimpinella anisum. - Studies comparing Pimpinella anisum to interventions or treatments unrelated to dyspepsia or symptom relief. - Studies lacking a clear description of the comparator/control intervention.
- Main Outcome
- The main outcome will be the proportion or rate of participants experiencing relief from dyspepsia symptoms after the intervention with Pimpinella anisum. Relief will be defined as a reduction in the severity or frequency of dyspepsia symptoms, such as postprandial fullness, early satiety, epigastric pain, and epigastric burning, as measured by validated assessment tools or self-reported measures. The measurement of symptom relief will be assessed at the end of the intervention period or the follow-up period, as specified in the included studies. Measures of effect The effect measure for the main outcome will be the relative risk (RR) of achieving dyspepsia symptom relief in the Pimpinella anisum intervention group compared to the comparator or control group. If feasible, risk differences (RD) and the number needed to treat (NNT) will also be calculated.
- Outcome Measure
- Additional Outcome
- The occurrence of any adverse events associated with Pimpinella anisum intervention will also be assessed. Adverse events will be recorded and categorized according to their severity and relation to the intervention. Measures of effect The occurrence of adverse events will be reported as frequencies or proportions.
- Study Method
- Intervention, Living systematic review, Meta-analysis, Systematic review
- Keyword
- Dyspepsia; Humans; Oils, Volatile; Pimpinella; Plant Extracts
- Contact
- Hiba Imran [email protected]
- Organisational Affiliation
- Funding Source
- This is a non-funded project.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Pakistan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-27
- Registration Date
- 2023-09-07
- Anticipated Start Date
- 2023-07-15
- Anticipated Completion Date
- 2023-12-03
- Title Cn
- 茴芹对缓解消化不良症状的效果：一项系统评价
- Title En
- The Effect of Pimpinella anisum on Relieving Symptoms of Dyspepsia: A Systematic Review
- Bilingual Status
- complete