Meta AnalysisID 6857
草药复方治疗高血压及高血压前期患者疗效与安全性比较的系统评价与网状Meta分析
CRD42023399293
1.What is the efficacy of 20 herbal compounds compare to placebo group for control hypertension in adults without history of hypertension crisis? 2.what is the safety of 20 herbal compounds using to control hypertension
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Record Fields
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- Meta Analysis Id
- 6857
- Evidence Id
- 15415
- Core Evidence Id
- 15415
- Source Meta Analysis Id
- 6843
- Herb2 Meta Analysis Id
- HBMA006843
- Crd Id
- CRD42023399293
- Title
- A systematic review and network meta-analysis to compare efficacy and safety of herbal compounds in hypertensive and pre-hypertensive patients
- Review Question
- 1.What is the efficacy of 20 herbal compounds compare to placebo group for control hypertension in adults without history of hypertension crisis? 2.what is the safety of 20 herbal compounds using to control hypertension in adults?
- Study Type Included
- we will include Randomized Controlled Trials(Related Systematic Reviews and Guidelines will be check for more additional studies)
- Condition Being Studied
- One of the most important risk factors for coronary heart disease is hypertension (HTN) that can reticently breakdown blood vessels, heart, brain and kidneys. The risk of cardiovascular disease increase as blood pressure rises to 115/75. It is appraised that 3.5 billion people among adult population have non-optimal systolic blood pressure (BP) levels (i.e., >110-115), and 874 million adults have a systolic BP ≥ 140 mmHg. Hence, around 25% of adults have HTN. The prevalence of HTN is increasing globally so that there will be 1.5 billion hypertensive patients in the world by 2025. According to the American heart association, about 16.5% of the global mortality can be credited to hypertension, of which 45% are caused by coronary heart disease. Most of these disorders are not curable and the current therapeutic strategies only aim at disease control. But even a small decrease in the systolic and diastolic blood pressures (e.g., 2–5 mmHg) cause a dramatic reduction in the hypertension complications like stroke and coronary heart disease.Thus, there is a rising trend towards using herbal medicine in health care generally and cardiovascular medicine.
- Participant
- adult populations (more than 18 y/o) with primary or secondary hypertension (elevated, stage 1 or 2) Patients without current or a history of HTN crisis.
- Animal
- Human Disease Modelled
- Intervention
- We are interested in below suggested antihypertensive herbal compounds; Garlic (Allium sativum L.) Celery (Apium graveolens) Grapefruit (Citrus × paradisi) Thyme (Thymus vulgaris) Ginger (Zingiber officinale) Brahmi (Bacopa monnieri) Cardamom (cardamon or cardamum) Chinese cat’s claw (Uncaria rhynchophylla) Cinnamon (Cinnamomumgenus) Ajwain (Trachyspermum ammi) Phyllanthus amarus (P. amarus) Hawthorn (Crataegus pinnatifida) saffron (Crocus sativus) Roselle (Hibiscus sabdariff) Barberry (Berberis vulgaris) Olive leaf extract (Olea europaea) Jujube (Ziziphus jujuba) Caucasian whortleberry (Vaccinium Arctostaphylos) Artichoke (Cynara Scolymus) mistletoe (Viscum Album)
- Comparator Control
- placebo, No treatment, Routine therapy, Any other control group
- Main Outcome
- Systolic Blood Pressure (SBP) Diastolic Blood Pressure (DBP) Measures of effect Treatment effects for the continuos outcomes will be estimated using mean difference (MD) with associated 95% CI
- Outcome Measure
- Additional Outcome
- Number of HTN crisis All cause of mortality Incidence of coronary artery disease (CAD) Incidence of cerebral vascular accident (CVA) Measures of effect Treatment effects will be estimated using odds ratio (OR) and corresponding 95% confidence intervals (CI) for dichotomous outcomes
- Study Method
- Intervention, Network meta-analysis, Systematic review
- Keyword
- Adult; Humans; Hypertension; Hypertensive Encephalopathy; Network Meta-Analysis
- Contact
- Parsa Ghaedzade [email protected]
- Organisational Affiliation
- Hormozgan University Of Medical Sciences-Bandar Abbas-Iran
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-08
- Registration Date
- 2023-08-19
- Anticipated Start Date
- 2023-03-10
- Anticipated Completion Date
- 2025-12-31
- Title Cn
- 草药复方治疗高血压及高血压前期患者疗效与安全性比较的系统评价与网状Meta分析
- Title En
- A systematic review and network meta-analysis to compare efficacy and safety of herbal compounds in hypertensive and pre-hypertensive patients
- Bilingual Status
- complete